OSBPL2

Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro). In conjunction with PLCB3, it may contribute to the control of keratinocyte proliferation and differentiation, probably through the regulation of the ERK pathway and the cell cycle. Involved in angiogenic signaling pathways such as VEGFR2 in endothelial cells. Controls LDL-cholesterol plasma membrane delivery, focal adhesion kinase (FAK) activation and PI(4,5)P2 generation, enhancing cell adhesion..

Function from UniProtKB (Q9H1P3), read 2026-09-23. CC BY 4.0.