Loading the page.
Proteins/UNIPROT:P49327
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain..
(Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication..
Function from UniProtKB (P49327), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
160 statements
160 statements · 6 reference databases · Subject: FASN · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, WikiPathways
110 reactions
CHEBI:15351+9proton+3malonyl-CoA+6NADPH(4-)3carbon dioxide+3CHEBI:1146900+3water+6NADP(3-)+octanoyl-CoA
Catalysed by FASN
Reaction pageLeft to rightBalancedEC 2.3.1.86cytosol
Human-GEM MAR01036CC BY 4.0Reference data
MAM00184c+
3 names
Resolves to: FASN
Catalysed by FASN
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85cytosol
Human-GEM MAR02150CC BY 4.0Reference data
MAM00184c+malonyl-CoACHEBI:1146900+MAM02442c
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 2.3.1.39cytosol
Human-GEM MAR02151CC BY 4.0Reference data
MAM01258c+proton+MAM02442cMAM00184c+MAM01254c+carbon dioxide
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 2.3.1.179cytosol
Human-GEM MAR02152CC BY 4.0Reference data
MAM01254c+proton+NADPH(4-)MAM00158c+NADP(3-)
Catalysed by FASN
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 2.3.1.86, 1.1.1.100cytosol
Human-GEM MAR02153CC BY 4.0Reference data
MAM00158cMAM01409c+water
Catalysed by FASN
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 4.2.1.59cytosol
Human-GEM MAR02154CC BY 4.0Reference data
MAM01409c+proton+NADPH(4-)MAM01411c+NADP(3-)
Catalysed by PECR or MECR or FASN
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 1.3.1.39cytosol
Human-GEM MAR02155CC BY 4.0Reference data
MAM01411c+proton+MAM02442cMAM00184c+MAM00881c+carbon dioxide
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 2.3.1.41, 2.3.1.179cytosol
Human-GEM MAR02156CC BY 4.0Reference data
MAM00881c+proton+NADPH(4-)MAM01635c+NADP(3-)
Catalysed by FASN
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 2.3.1.86, 1.1.1.100cytosol
Human-GEM MAR02157CC BY 4.0Reference data
MAM01635cMAM00052c+water
Catalysed by FASN
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 4.2.1.59cytosol
Human-GEM MAR02158CC BY 4.0Reference data
MAM00052c+proton+NADPH(4-)MAM02121c+NADP(3-)
Catalysed by FASN
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 1.3.1.39cytosol
Human-GEM MAR02159CC BY 4.0Reference data
proton+MAM02121c+MAM02442cMAM00184c+MAM00891c+carbon dioxide
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 2.3.1.41, 2.3.1.179cytosol
Human-GEM MAR02160CC BY 4.0Reference data