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Proteins/UNIPROT:Q15738
Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By similarity). Also plays a role in the regulation of the endocytic trafficking of EGFR (By similarity)..
Function from UniProtKB (Q15738), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
228 statements
228 statements · 3 reference databases · Subject: NSDHL · Sources: Hetionet, Reactome, WikiPathways
19 reactions
MAM00953r+NADP(3-)MAM00809r+carbon dioxide+proton+NADPH(4-)
Catalysed by NSDHL
Reaction pageLeft to rightBalancedEC 1.1.1.170endoplasmic reticulum
Human-GEM MAR00113CC BY 4.0Reference data
MAM00953r+NAD(+)MAM00809r+carbon dioxide+proton+NADH(2-)
Catalysed by
2 names
Resolves to: NSDHL
Reaction pageLeft to rightBalancedEC 1.1.1.170endoplasmic reticulum
Human-GEM MAR00114CC BY 4.0Reference data
MAM00809r+NADP(3-)+dioxygencarbon dioxide+proton+NADPH(4-)+MAM04082r
Catalysed by NSDHL
Reaction pageLeft to rightBalancedEC 1.1.1.170endoplasmic reticulum
Human-GEM MAR00117CC BY 4.0Reference data
MAM00809r+NAD(+)+dioxygencarbon dioxide+proton+NADH(2-)+MAM04082r
Reaction pageLeft to rightBalancedendoplasmic reticulum
Human-GEM MAR00118CC BY 4.0Reference data
MAM00953c+NADP(3-)MAM00809c+carbon dioxide+proton+NADPH(4-)
Catalysed by NSDHL
Reaction pageLeft to rightBalancedEC 1.1.1.170cytosol
Human-GEM MAR01495CC BY 4.0Reference data
MAM00953c+NAD(+)MAM00809c+carbon dioxide+proton+NADH(2-)
Catalysed by NSDHL
Reaction pageLeft to rightBalancedEC 1.1.1.170cytosol
Human-GEM MAR01496CC BY 4.0Reference data
MAM00955c+NADP(3-)MAM01067c+carbon dioxide+proton+NADPH(4-)
Catalysed by NSDHL
Reaction pageLeft to rightBalancedEC 1.1.1.170cytosol
Human-GEM MAR01505CC BY 4.0Reference data
MAM00954c+NADP(3-)MAM00966c+carbon dioxide+proton+NADPH(4-)
Catalysed by NSDHL
Reaction pageLeft to rightBalancedEC 1.1.1.170cytosol
Human-GEM MAR01546CC BY 4.0Reference data
MAM00956c+NADP(3-)MAM01068c+carbon dioxide+proton+NADPH(4-)
Catalysed by NSDHL
Reaction pageLeft to rightBalancedEC 1.1.1.170cytosol
Human-GEM MAR01551CC BY 4.0Reference data
CHEBI:64925+NADP(3-)CHEBI:50593+carbon dioxide+NADPH(4-)
Catalysed by NSDHL
Reaction pageLeft to rightBalanced
Rhea RHEA:33447CC BY 4.0Reference data
CHEBI:143575+NADP(3-)CHEBI:52386+carbon dioxide+NADPH(4-)
Catalysed by NSDHL
Reaction pageLeft to rightBalanced
Rhea RHEA:33455CC BY 4.0Reference data
CHEBI:136966+NADP(3-)CHEBI:47788+carbon dioxide+NADPH(4-)
Catalysed by NSDHL
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:34771CC BY 4.0Reference data