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Proteins/UNIPROT:P10109
Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity)..
Function from UniProtKB (P10109), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
188 statements
188 statements · 5 reference databases · Subject: FDX1 · Sources: Hetionet, Human-GEM, Reactome, UniProt, WikiPathways
1 reaction
MAM00210m+3proton+NADPH(4-)+2S-adenosyl-L-methionine+tetra-mu3-sulfido-tetrairon(2+)MAM00208m+2MAM01098m+4iron(2+)+2hydrogen sulfide+2L-methionine+NADP(3-)
4 names
Resolves to: FDX1
Reaction pageLeft to rightBalancedEC 2.8.1.8mitochondrial matrix
Human-GEM MAR06403CC BY 4.0Reference data