a ganglioside GD1b (d18:1(4E))

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

118 compounds within 3 steps: 6 in 1, 15 in 2, 97 in 3

One step

alpha-D-galactoseReach from here →
1. Beta-Galactosidase, Lysosomal
Catalysed by GLB1lysosome
N-acetylneuraminateReach from here →
1. a ganglioside GD1b (d18:1(4E)) + H2O = a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate
Catalysed by NEU3
N-acetyl-beta-neuraminic acidReach from here →
1. Sialidase, Cytosol (Neu2)
Catalysed by NEU2cytosolOne of 2 routes
a ganglioside GM1 (d18:1(4E))Reach from here →
1. Sialidase, Cytosol (Neu2)
Catalysed by NEU2cytosolOne of 3 routes
a ganglioside GT1b (d18:1(4E))Reach from here →
1. beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by ST3GAL1, ST3GAL4, ST3GAL2cytosolOne of 3 routes
a ganglioside GD2 (d18:1(4E))Reach from here →
1. Beta-Galactosidase, Lysosomal
Catalysed by GLB1lysosome

Two steps

pyruvateReach from here →
1. Sialidase, Cytosol (Neu2)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by NEU2, NPLcytosol
galactitolReach from here →
1. Beta-Galactosidase, Lysosomal
2. galactitol:NADP+ 1-oxidoreductase
Catalysed by GLB1, AKR1B1lysosome, cytosol
aldehydo-N-acetyl-D-mannosamineReach from here →

Three steps

Sialidase, Cytosol (Neu2)

N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

Catalysed by NEU2, NPLcytosol

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))Reach from here →

Catalysed by GLB1, LCT, GLB1Llysosome, extracellular space

beta-D-galactoseReach from here →

Catalysed by GLB1, GALMlysosome, nucleusOne of 2 routes

a ganglioside GA1 (d18:1(4E))Reach from here →

Catalysed by NEU2, NEU3cytosol

N-glycoloylneuraminateReach from here →

Catalysed by NEU2cytosol

CMP-N-acetyl-beta-neuraminateReach from here →

Catalysed by NEU2, CMAScytosol, nucleusOne of 2 routes

alpha-D-galactose 1-phosphateReach from here →

Catalysed by GLB1, GALK1, GALK2lysosome, cytosolOne of 2 routes

a ganglioside GM2 (d18:1(4E))Reach from here →

Catalysed by GLB1, NEU3lysosome, extracellular spaceOne of 5 routes

a ganglioside GD3 (d18:1(4E))Reach from here →

Catalysed by GLB1, HEXA, HEXBlysosome

a ganglioside GD1a (d18:1(4E))Reach from here →

Catalysed by NEU2, ST3GAL1, ST3GAL4, ST3GAL2cytosolOne of 3 routes

a ganglioside GQ1b (d18:1(4E))Reach from here →

Catalysed by ST3GAL1, ST3GAL4, ST3GAL2, ST8SIA5cytosolOne of 3 routes

a ganglioside GQ1balpha (d18:1(4E))Reach from here →

Catalysed by ST3GAL1, ST3GAL4, ST3GAL2, ST6GALNAC6cytosol

a ganglioside Fuc-GM1 (d18:1(4E))Reach from here →

Catalysed by NEU2, FUT2cytosol

Catalysed by NEU2, NPL, SLC16A4, SLC16A5 and 4 more

cytosol, extracellular space

One of 2 routes

an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivativeReach from here →

Catalysed by NEU2, CMAS, ST6GAL1, ST6GAL2cytosol, nucleus

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivativeReach from here →

Catalysed by NEU2, CMAS, ST3GAL3, ST3GAL4 and 1 morecytosol, nucleus

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivativeReach from here →

Catalysed by NEU2, CMAS, ST3GAL4cytosol, nucleus

acetoacetateReach from here →

Catalysed by NEU2, NPLcytosol, mitochondrial matrixOne of 4 routes

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivativeReach from here →

Catalysed by NEU2, CMAS, ST3GAL1, ST3GAL4 and 1 morecytosol, nucleus

an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivativeReach from here →

Catalysed by NEU2, CMAS, ST8SIA3, ST8SIA1cytosol, nucleus

a globoside MSGGReach from here →

Catalysed by NEU2, CMAS, ST3GAL2cytosol, nucleus

a globoside DSGGReach from here →

Catalysed by NEU2, CMAS, ST6GALNAC3, ST6GALNAC6cytosol, nucleus

a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivativeReach from here →

Catalysed by NEU2, CMAS, ST6GALNAC1, ST6GALNAC2cytosol, nucleus

a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer(d18:1(4E))Reach from here →

Catalysed by NEU2, CMAS, ST3GAL6cytosol, nucleus

an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc derivativeReach from here →

Catalysed by NEU2, CMAS, ST6GALNAC3, ST6GALNAC4cytosol, nucleus

acetylpyruvateReach from here →

Catalysed by NEU2, NPL, FAHD1cytosol

all-trans-retinoic acidReach from here →

Catalysed by NEU2, NPL, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

(S)-malateReach from here →

Catalysed by NEU2, NPL, ME2cytosolOne of 2 routes

N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamineReach from here →

Catalysed by NEU2, CMAS, ST6GALNAC4cytosol, nucleus

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by NEU2, NPL, AGXT2cytosol, mitochondrial matrix

oxaloacetateReach from here →

Catalysed by NEU2, NPL, PCcytosol, mitochondrial matrixOne of 3 routes

(S)-lactateReach from here →

Catalysed by NEU2, NPL, LDHA, LDHB and 3 morecytosol

2-oxobutanoateReach from here →

Catalysed by NEU2, NPL, AGXT2cytosol

2-oxoglutaramateReach from here →

Catalysed by NEU2, NPL, KYAT1cytosolOne of 2 routes

3-fumarylpyruvateReach from here →

Catalysed by NEU2, NPL, FAHD1cytosol

(R)-3-hydroxybutyric acidReach from here →

Catalysed by NEU2, NPL, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))Reach from here →

Catalysed by GLB1, LCT, GLB1L, B3GNT5lysosome, extracellular space, cytosolOne of 3 routes

3-hydroxypyruvateReach from here →

Catalysed by NEU2, NPL, AGXTcytosol

aceneuramateReach from here →

Catalysed by NEU2, NPLcytosolOne of 2 routes

5'-deoxyadenosineReach from here →

Catalysed by NEU2, NPL, TYW1B, TYW1cytosol

dTDPReach from here →

Catalysed by NEU2, NPL, PKM, PKLRcytosol