Compound

a ganglioside GT1b (d18:1(4E))

An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of ganglioside GT1b; major species at pH 7.3.

Definition from ChEBI (CHEBI:78452), read 2026-09-23. CC BY 4.0.

CHEBI:78452ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound, anion
Formula: C78H127N5O47R
Mass: 1886.851 g/mol
Charge: -3
SMILES: *C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O[C@]5(C(=O)[O-])C[C@H](O)[C@@H](NC(C)=O)[C@]([H])([C@H](O)[C@H](O)CO)O5)[C@H]4O)[C@H]3NC(C)=O)[C@H](O[C@]3(C(=O)[O-])C[C@H](O)[C@@H](NC(C)=O)[C@]([H])([C@H](O)[C@@H](CO)O[C@]4(C(=O)[O-])C[C@H](O)[C@@H](NC(C)=O)[C@]([H])([C@H](O)[C@H](O)CO)O4)O3)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)/C=C/CCCCCCCCCCCCC
Look it up: ChEBI

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

8 entities

8 entities reached.

0 reported hops8 assembled from the scaffold

What the reference databases state

Statements

13 statements

13 statements · 2 reference databases · Subject: a ganglioside GT1b (d18:1(4E)) · Sources: Human-GEM, Rhea

Order

a ganglioside GT1b (d18:1(4E)) is a substrate of NEU1ProteinHuman-GEM MAR00845Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of NEU2ProteinHuman-GEM MAR00845Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of NEU3ProteinHuman-GEM MAR12073Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of NEU3ProteinHuman-GEM MAR00845Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of NEU4ProteinHuman-GEM MAR00845Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of ST6GALNAC6ProteinRhea RHEA:41976Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of ST6GALNAC6ProteinHuman-GEM MAR00848Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of ST6GALNAC6ProteinHuman-GEM MAR08178Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of ST8SIA1ProteinRhea RHEA:41772Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of ST8SIA5ProteinHuman-GEM MAR08181Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of ST8SIA5ProteinRhea RHEA:41772Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of ST8SIA5ProteinHuman-GEM MAR00846Inferred only

Show the remaining 1

a ganglioside GT1b (d18:1(4E)) is a substrate of ST8SIA6ProteinRhea RHEA:41772Inferred only

Reactions

17 reactions

CMP-N-acetyl-beta-neuraminate+a ganglioside GD1b (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT1b (d18:1(4E))+proton
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4cytosol
Human-GEM MAR00844CC BY 4.0Reference data
a ganglioside GT1b (d18:1(4E))+watera ganglioside GD1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00845CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GT1b (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GQ1b (d18:1(4E))+proton
Catalysed by ST8SIA5
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-cytosol
Human-GEM MAR00846CC BY 4.0Reference data
a ganglioside GQ1b (d18:1(4E))+watera ganglioside GT1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00847CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GT1b (d18:1(4E))cytidine 5'-monophosphate+MAM02024c+proton
Catalysed by ST6GALNAC6
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-cytosol
Human-GEM MAR00848CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1a (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT1b (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8cytosol
Human-GEM MAR00853CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GT1b (d18:1(4E))cytidine 5'-monophosphate+MAM02024g+proton
Catalysed by ST6GALNAC6
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08178CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GT1b (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GQ1b (d18:1(4E))+proton
Catalysed by ST8SIA5
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08181CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1b (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT1b (d18:1(4E))+proton
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4Golgi apparatus
Human-GEM MAR08189CC BY 4.0Reference data
a ganglioside GT1b (d18:1(4E))+watera ganglioside GD1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU3
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18extracellular space
Human-GEM MAR12073CC BY 4.0Reference data
a ganglioside GQ1b (d18:1(4E))+watera ganglioside GT1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU3
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18extracellular space
Human-GEM MAR12075CC BY 4.0Reference data
a ganglioside GT1b (d18:1(4E))
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR12139CC BY 4.0Reference data

Show the remaining 5

Other names

4 names

Resolves to: a ganglioside GT1b (d18:1(4E))

Also called: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminosyl-(2->8)-alphaN-acetylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11')-ceramide(3-)Ganglioside GT1b (d18:1(4E))GT1b(d18:1(4E))α-N-acetylneuraminosyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminosyl-(2→8)-αN-acetylneuraminosyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1')-ceramide(3−)