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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q11203

ST3GAL3

Protein·UNIPROT:Q11203CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

Open in the graph

Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc..

Function from UniProtKB (Q11203), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

complex neurodevelopmental disorder has a germline basis in ST3GAL3DiseaseGenCC HGNC:10866|MONDO:0100038Inferred only
developmental and epileptic encephalopathy, 15 has a germline basis in ST3GAL3DiseaseGenCC HGNC:10866|MONDO:0014003Inferred only
intellectual disability, autosomal recessive 12 has a germline basis in ST3GAL3DiseaseGenCC HGNC:10866|MONDO:0012612Inferred only

Statements

54 statements

54 statements · 5 reference databases · Subject: ST3GAL3 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea

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CWH43 covaries with ST3GAL3ProteinHetionet hetionet:covaries:6487-80157Inferred only
ST3GAL3 is expressed in hindlimb stylopod muscleAnatomyBgee ENSG00000126091Inferred only
ACTG1 interacts with ST3GAL3ProteinHetionet hetionet:interacts:6487-71Inferred only
RPL8 interacts with ST3GAL3ProteinHetionet hetionet:interacts:6132-6487Inferred only
ST3GAL3 interacts with SCAMP2ProteinHetionet hetionet:interacts:10066-6487Inferred only
ST3GAL3 interacts with TTRProteinHetionet hetionet:interacts:6487-7276Inferred only
ST3GAL3 interacts with ZBTB5ProteinHetionet hetionet:interacts:6487-9925Inferred only
ST3GAL3 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
ST3GAL3 participates in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinPathwayReactome R-HSA-446193Inferred only
ST3GAL3 participates in Blood group systems biosynthesisPathwayReactome R-HSA-9033658Inferred only
ST3GAL3 participates in Defective ST3GAL3 causes MCT12 and EIEE15PathwayReactome R-HSA-3656243Inferred only
ST3GAL3 participates in DiseasePathwayReactome R-HSA-1643685Inferred only

Show the remaining 42

ST3GAL3 participates in Diseases associated with glycosaminoglycan metabolismPathwayReactome R-HSA-3560782Inferred only
ST3GAL3 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
ST3GAL3 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
ST3GAL3 participates in Glycosaminoglycan metabolismPathwayReactome R-HSA-1630316Inferred only
ST3GAL3 participates in Glycosphingolipid biosynthesisPathwayReactome R-HSA-9840309Inferred only
ST3GAL3 participates in Glycosphingolipid metabolismPathwayReactome R-HSA-1660662Inferred only
ST3GAL3 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
ST3GAL3 participates in Keratan sulfate biosynthesisPathwayReactome R-HSA-2022854Inferred only
ST3GAL3 participates in Keratan sulfate/keratin metabolismPathwayReactome R-HSA-1638074Inferred only
ST3GAL3 participates in Late SARS-CoV-2 Infection EventsPathwayReactome R-HSA-9772573Inferred only
ST3GAL3 participates in Lewis blood group biosynthesisPathwayReactome R-HSA-9037629Inferred only
ST3GAL3 participates in Maturation of protein 3aPathwayReactome R-HSA-9683673Inferred only
ST3GAL3 participates in Maturation of protein 3aPathwayReactome R-HSA-9694719Inferred only
ST3GAL3 participates in Maturation of spike proteinPathwayReactome R-HSA-9694548Inferred only
ST3GAL3 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
ST3GAL3 participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only
ST3GAL3 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
ST3GAL3 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ST3GAL3 participates in O-linked glycosylationPathwayReactome R-HSA-5173105Inferred only
ST3GAL3 participates in O-linked glycosylation of mucinsPathwayReactome R-HSA-913709Inferred only
ST3GAL3 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ST3GAL3 participates in Pre-NOTCH Expression and ProcessingPathwayReactome R-HSA-1912422Inferred only
ST3GAL3 participates in Pre-NOTCH Processing in GolgiPathwayReactome R-HSA-1912420Inferred only
ST3GAL3 participates in SARS-CoV InfectionsPathwayReactome R-HSA-9679506Inferred only
ST3GAL3 participates in SARS-CoV-1 InfectionPathwayReactome R-HSA-9678108Inferred only
ST3GAL3 participates in SARS-CoV-2 InfectionPathwayReactome R-HSA-9694516Inferred only
ST3GAL3 participates in Sialic acid metabolismPathwayReactome R-HSA-4085001Inferred only
ST3GAL3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ST3GAL3 participates in Signaling by NOTCHPathwayReactome R-HSA-157118Inferred only
ST3GAL3 participates in Sphingolipid metabolismPathwayReactome R-HSA-428157Inferred only
ST3GAL3 participates in Synthesis of substrates in N-glycan biosythesisPathwayReactome R-HSA-446219Inferred only
ST3GAL3 participates in Termination of O-glycan biosynthesisPathwayReactome R-HSA-977068Inferred only
ST3GAL3 participates in Translation of Structural ProteinsPathwayReactome R-HSA-9683701Inferred only
ST3GAL3 participates in Translation of Structural ProteinsPathwayReactome R-HSA-9694635Inferred only
ST3GAL3 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) is a substrate of ST3GAL3CompoundHuman-GEM MAR08318Inferred only
a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) is a substrate of ST3GAL3CompoundHuman-GEM MAR00861Inferred only
a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative is a substrate of ST3GAL3CompoundRhea RHEA:52316Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST3GAL3CompoundHuman-GEM MAR00861Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST3GAL3CompoundHuman-GEM MAR08318Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST3GAL3CompoundRhea RHEA:52316Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST3GAL3CompoundHuman-GEM MAR07335Inferred only

Reactions

4 reactions

CMP-N-acetyl-beta-neuraminate+a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))MAM00808c+cytidine 5'-monophosphate
Catalysed by ST3GAL4 or ST3GAL3
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.6cytosol
Human-GEM MAR00861CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02323gcytidine 5'-monophosphate+proton+MAM02201g
Catalysed by

Other names

9 names

Resolves to: ST3GAL3

Also called: Alpha 2,3-ST 3Beta-galactoside alpha-2,3-sialyltransferase 3Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferaseN-acetyllactosaminide alpha-2,3-sialyltransferaseSialyltransferase 6SIAT6ST3Gal IIIST3GalIIIST3N

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Reaction pageLeft to rightBalance undeterminableEC 2.4.3.6Golgi apparatus

Human-GEM MAR07335CC BY 4.0Reference data

CMP-N-acetyl-beta-neuraminate+a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))MAM01264g+cytidine 5'-monophosphate+proton

Catalysed by ST3GAL4 or ST3GAL3

Reaction pageLeft to rightBalance undeterminableEC 2.4.3.6Golgi apparatus

Human-GEM MAR08318CC BY 4.0Reference data

a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative+CMP-N-acetyl-beta-neuraminatean N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative+CMP+hydron

Catalysed by ST3GAL3 or ST3GAL4 or ST3GAL6

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:52316CC BY 4.0Reference data