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Proteins/UNIPROT:Q9H4F1
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. Prefers O-glycans to glycoproteins or glycolipids..
Function from UniProtKB (Q9H4F1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
69 statements
69 statements · 4 reference databases · Subject: ST6GALNAC4 · Sources: Hetionet, Human-GEM, Reactome, Rhea
7 reactions
CMP-N-acetyl-beta-neuraminate+MAM02010ccytidine 5'-monophosphate+a ganglioside GD1a (d18:1(4E))+proton
Catalysed by ST6GALNAC5 or ST6GALNAC4 or ST6GALNAC6 or ST6GALNAC3
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-, 2.4.3.7cytosol
Human-GEM MAR00823CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02010gcytidine 5'-monophosphate
9 names
Resolves to: ST6GALNAC4
Catalysed by ST6GALNAC5 or ST6GALNAC4 or ST6GALNAC6 or ST6GALNAC3
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-, 2.4.3.7Golgi apparatus
Human-GEM MAR08168CC BY 4.0Reference data
a ganglioside GM1b (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GD1alpha (d18:1(4E))+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC6 or ST6GALNAC5 or ST6GALNAC4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41968CC BY 4.0Reference data
an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative+CMP-N-acetyl-beta-neuraminatean alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc derivative+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:53896CC BY 4.0Reference data
3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-seryl-[protein]+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC6 or ST6GALNAC4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:65280CC BY 4.0Reference data
3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-threonyl-[protein]+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC6 or ST6GALNAC4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:65284CC BY 4.0Reference data
N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine+CMP-N-acetyl-beta-neuraminateN-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine+CMP+hydron
Catalysed by ST6GALNAC4
Reaction pageLeft to rightBalanced
Rhea RHEA:65288CC BY 4.0Reference data