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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:O15466

ST8SIA5

Protein·UNIPROT:O15466Alpha-2,8-sialyltransferase 8E

Open in the graph

Involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, GP1c and GT3 from GD1a, GT1b, GM1b and GD3 respectively..

Function from UniProtKB (O15466), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

43 statements

43 statements · 5 reference databases · Subject: ST8SIA5 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

Search this listOrder

RPS6KC1 covaries with ST8SIA5ProteinHetionet hetionet:covaries:26750-29906Inferred only
TMPRSS11B covaries with ST8SIA5ProteinHetionet hetionet:covaries:132724-29906Inferred only
ST8SIA5 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
ST8SIA5 participates in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinPathwayReactome R-HSA-446193Inferred only
ST8SIA5 participates in Ganglio series sphingolipid metabolismPathwayWikiPathways WP5299Inferred only
ST8SIA5 participates in Ganglio sphingolipid metabolismPathwayWikiPathways WP1423Inferred only
ST8SIA5 participates in Glycosphingolipid biosynthesisPathwayReactome R-HSA-9840309Inferred only
ST8SIA5 participates in Glycosphingolipid metabolismPathwayReactome R-HSA-1660662Inferred only
ST8SIA5 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
ST8SIA5 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
ST8SIA5 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ST8SIA5 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Show the remaining 31

ST8SIA5 participates in Sialic acid metabolismPathwayReactome R-HSA-4085001Inferred only
ST8SIA5 participates in Sphingolipid metabolismPathwayReactome R-HSA-428157Inferred only
ST8SIA5 participates in Synthesis of substrates in N-glycan biosythesisPathwayReactome R-HSA-446219Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of ST8SIA5CompoundHuman-GEM MAR08182Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of ST8SIA5CompoundRhea RHEA:41768Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of ST8SIA5CompoundHuman-GEM MAR00839Inferred only
a ganglioside GD3 (d18:1(4E)) is a substrate of ST8SIA5CompoundRhea RHEA:41764Inferred only
a ganglioside GD3 (d18:1(4E)) is a substrate of ST8SIA5CompoundHuman-GEM MAR08180Inferred only
a ganglioside GD3 (d18:1(4E)) is a substrate of ST8SIA5CompoundHuman-GEM MAR00855Inferred only
a ganglioside GM1b (d18:1(4E)) is a substrate of ST8SIA5CompoundRhea RHEA:47576Inferred only
a ganglioside GQ1c (d18:1(4E)) is a substrate of ST8SIA5CompoundRhea RHEA:47592Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of ST8SIA5CompoundHuman-GEM MAR00846Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of ST8SIA5CompoundRhea RHEA:41772Inferred only
a ganglioside GT1b (d18:1(4E)) is a substrate of ST8SIA5CompoundHuman-GEM MAR08181Inferred only
a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) is a substrate of ST8SIA5CompoundHuman-GEM MAR08327Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundHuman-GEM MAR00855Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundHuman-GEM MAR08183Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundHuman-GEM MAR00822Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundHuman-GEM MAR00839Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundHuman-GEM MAR00846Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundHuman-GEM MAR08171Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundHuman-GEM MAR08177Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundHuman-GEM MAR08180Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundHuman-GEM MAR08181Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundHuman-GEM MAR08182Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundHuman-GEM MAR08327Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundRhea RHEA:41764Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundRhea RHEA:41768Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundRhea RHEA:41772Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundRhea RHEA:47576Inferred only
CMP-N-acetyl-beta-neuraminate is a substrate of ST8SIA5CompoundRhea RHEA:47592Inferred only

Reactions

16 reactions

CMP-N-acetyl-beta-neuraminate+MAM02010ccytidine 5'-monophosphate+MAM01945c+proton
Catalysed by ST8SIA5
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-cytosol
Human-GEM MAR00822CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1a (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT1a (d18:1(4E))+proton
Catalysed by ST8SIA5

Other names

5 names

Resolves to: ST8SIA5

Also called: Sialyltransferase 8ESialyltransferase St8Sia VSIAT8-ESIAT8EST8SiaV

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Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-cytosol

Human-GEM MAR00839CC BY 4.0Reference data

CMP-N-acetyl-beta-neuraminate+a ganglioside GT1b (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GQ1b (d18:1(4E))+proton

Catalysed by ST8SIA5

Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-cytosol

Human-GEM MAR00846CC BY 4.0Reference data

CMP-N-acetyl-beta-neuraminate+a ganglioside GD3 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT3 (d18:1(4E))+proton

Catalysed by ST8SIA5 or ST8SIA1

Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8, 2.4.99.-cytosol

Human-GEM MAR00855CC BY 4.0Reference data

CMP-N-acetyl-beta-neuraminate+MAM02010gcytidine 5'-monophosphate+MAM01945g+proton

Catalysed by ST8SIA5

Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus

Human-GEM MAR08171CC BY 4.0Reference data

CMP-N-acetyl-beta-neuraminate+MAM02025gcytidine 5'-monophosphate+MAM02018g+proton

Catalysed by ST8SIA5

Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus

Human-GEM MAR08177CC BY 4.0Reference data

CMP-N-acetyl-beta-neuraminate+a ganglioside GD3 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT3 (d18:1(4E))+proton

Catalysed by ST8SIA5

Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus

Human-GEM MAR08180CC BY 4.0Reference data

CMP-N-acetyl-beta-neuraminate+a ganglioside GT1b (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GQ1b (d18:1(4E))+proton

Catalysed by ST8SIA5

Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus

Human-GEM MAR08181CC BY 4.0Reference data

CMP-N-acetyl-beta-neuraminate+a ganglioside GD1a (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT1a (d18:1(4E))+proton

Catalysed by ST8SIA5

Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus

Human-GEM MAR08182CC BY 4.0Reference data

CMP-N-acetyl-beta-neuraminate+MAM02025gcytidine 5'-monophosphate+MAM02019g+proton

Catalysed by ST8SIA5

Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus

Human-GEM MAR08183CC BY 4.0Reference data

CMP-N-acetyl-beta-neuraminate+a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))MAM00744g+cytidine 5'-monophosphate+proton

Catalysed by ST8SIA5

Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus

Human-GEM MAR08327CC BY 4.0Reference data

a ganglioside GD3 (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GT3 (d18:1(4E))+CMP+hydron

Catalysed by ST8SIA5 or ST8SIA1

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:41764CC BY 4.0Reference data

Show the remaining 4