a ganglioside GM1 (d18:1(4E))

1. a ganglioside GM1 (d18:1(4E)) + H2O = a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate

Catalysed by NEU3

1. beta-galactosidase (GM1)

Catalysed by LCT, GLB1, GLB1L, TMPPEcytosolOne of 4 routes

1. a ganglioside GM1 (d18:1(4E)) + H2O = a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate

Catalysed by NEU3

1. Sialidase, Cytosol (Neu2)

Catalysed by NEU2cytosol

1. beta-galactosidase (GM1)

Catalysed by LCT, GLB1, GLB1L, TMPPEcytosolOne of 4 routes

1. beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)

Catalysed by ST3GAL1, ST3GAL4, ST3GAL2cytosolOne of 3 routes

1. a ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GM1 (d18:1(4E)) + GDP + H(+)

Catalysed by FUT2

1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)

Catalysed by ST8SIA1cytosol

1. Sialidase, Cytosol (Neu2)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

Catalysed by NEU2, NPLcytosol

1. beta-galactosidase (GM1)
2. galactitol:NADP+ 1-oxidoreductase

Catalysed by LCT, GLB1, GLB1L, TMPPE and 1 morecytosol

1. Sialidase, Cytosol (Neu2)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)

Catalysed by NEU2, NPL, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

1. Sialidase, Cytosol (Neu2)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)