Compound

a ganglioside GD1a (d18:1(4E))

An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of ganglioside GD1a; major species at pH 7.3.

Definition from ChEBI (CHEBI:78445), read 2026-09-23. CC BY 4.0.

CHEBI:78445ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound, anion
Formula: C67H111N4O39R
Mass: 1596.604 g/mol
Charge: -2
SMILES: *C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O[C@]5(C(=O)[O-])C[C@H](O)[C@@H](NC(C)=O)[C@]([H])([C@H](O)[C@H](O)CO)O5)[C@H]4O)[C@H]3NC(C)=O)[C@H](O[C@]3(C(=O)[O-])C[C@H](O)[C@@H](NC(C)=O)[C@]([H])([C@H](O)[C@H](O)CO)O3)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)/C=C/CCCCCCCCCCCCC
Look it up: ChEBI

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

8 entities

8 entities reached.

0 reported hops8 assembled from the scaffold

What the reference databases state

Statements

19 statements

19 statements · 2 reference databases · Subject: a ganglioside GD1a (d18:1(4E)) · Sources: Human-GEM, Rhea

Order

a ganglioside GD1a (d18:1(4E)) is a substrate of NEU1ProteinHuman-GEM MAR12077Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of NEU1ProteinHuman-GEM MAR00838Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of NEU2ProteinHuman-GEM MAR12066Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of NEU2ProteinHuman-GEM MAR00838Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of NEU3ProteinRhea RHEA:47856Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of NEU3ProteinHuman-GEM MAR00838Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of NEU3ProteinHuman-GEM MAR12077Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of NEU3ProteinHuman-GEM MAR12071Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of NEU4ProteinRhea RHEA:47856Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of NEU4ProteinHuman-GEM MAR00838Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of ST6GALNAC6ProteinHuman-GEM MAR08175Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of ST6GALNAC6ProteinHuman-GEM MAR00840Inferred only

Show the remaining 7

a ganglioside GD1a (d18:1(4E)) is a substrate of ST6GALNAC6ProteinRhea RHEA:41972Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of ST8SIA1ProteinHuman-GEM MAR00853Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of ST8SIA1ProteinRhea RHEA:41768Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of ST8SIA5ProteinRhea RHEA:41768Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of ST8SIA5ProteinHuman-GEM MAR00839Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of ST8SIA5ProteinHuman-GEM MAR08182Inferred only
a ganglioside GD1a (d18:1(4E)) is a substrate of ST8SIA6ProteinRhea RHEA:41768Inferred only

Reactions

22 reactions

CMP-N-acetyl-beta-neuraminate+MAM02010ccytidine 5'-monophosphate+a ganglioside GD1a (d18:1(4E))+proton
Catalysed by ST6GALNAC5 or ST6GALNAC4 or ST6GALNAC6 or ST6GALNAC3
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-, 2.4.3.7cytosol
Human-GEM MAR00823CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM1 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD1a (d18:1(4E))+proton
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4cytosol
Human-GEM MAR00837CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+watera ganglioside GM1 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00838CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1a (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT1a (d18:1(4E))+proton
Catalysed by ST8SIA5
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-cytosol
Human-GEM MAR00839CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1a (d18:1(4E))cytidine 5'-monophosphate+MAM02029c+proton
Catalysed by ST6GALNAC6
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-cytosol
Human-GEM MAR00840CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1a (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT1b (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8cytosol
Human-GEM MAR00853CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1a (d18:1(4E))cytidine 5'-monophosphate+MAM02029g+proton
Catalysed by ST6GALNAC6
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08175CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1a (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GT1a (d18:1(4E))+proton
Catalysed by ST8SIA5
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08182CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM1 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD1a (d18:1(4E))+proton
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4Golgi apparatus
Human-GEM MAR08188CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+waterN-acetyl-beta-neuraminic acid+a ganglioside GM1 (d18:1(4E))
Catalysed by NEU2
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR12066CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+waterN-acetyl-beta-neuraminic acid+a ganglioside GM1 (d18:1(4E))
Catalysed by NEU3
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18extracellular space
Human-GEM MAR12071CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+waterN-acetyl-beta-neuraminic acid+a ganglioside GM1 (d18:1(4E))
Catalysed by NEU3 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18nucleus
Human-GEM MAR12077CC BY 4.0Reference data

Show the remaining 10

Other names

13 names

Resolves to: a ganglioside GD1a (d18:1(4E))

Also called: alpha-NeuNAc-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-NeuNAc-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(11')-Cer(2-)alpha-NeupNAc-(2->3)-beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->4)-[alpha-NeupNAc-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp-(11')-Cer(2-)Ganglioside GD1a (d18:1(4E))ganglioside GD1a(2-)ganglioside GD1a(2−)GD1a(d18:1(4E))MG(12:0/0:0/0:0)NeuAc(alpha2-3)Gal(beta1-3)GalNAc(beta1-4)[NeuAc(alpha2-3)]Gal(beta1-4)Glc(beta1-1)Cer(2-)NeuAc(α2-3)Gal(β1-3)GalNAc(β1-4)[NeuAc(α2-3)]Gal(β1-4)Glc(β1-1)Cer(2−)NeuAcalpha2-3Galbeta1-3GalNAcbeta1-4(NeuAcalpha2-3)Galbeta1-4Glcbeta1-1Cer(2-)NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ1-1Cer(2−)α-NeuNAc-(2→3)-β-D-Gal-(1→3)-β-D-GalNAc-(1→4)-[α-NeuNAc-(2→3)]-β-D-Gal-(1→4)-β-D-Glc-(1↔1')-Cer(2−)α-NeupNAc-(2→3)-β-D-Galp-(1→3)-β-D-GalpNAc-(1→4)-[α-NeupNAc-(2→3)]-β-D-Galp-(1→4)-β-D-Glcp-(1↔1')-Cer(2−)