a ganglioside GM2 (d18:1(4E))

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

114 compounds within 3 steps: 7 in 1, 11 in 2, 96 in 3

One step

a ganglioside GA2 (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GM2)
Catalysed by NEU4, NEU1, NEU3, NEU2cytosolOne of 2 routes
N-acetyl-beta-D-galactosamineReach from here →
1. a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine
Catalysed by HEXA, HEXB
N-acetylneuraminateReach from here →
1. a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate
Catalysed by NEU4, NEU3
N-acetyl-beta-neuraminic acidReach from here →
1. exo-alpha-sialidase (GM2)
Catalysed by NEU4, NEU1, NEU3, NEU2cytosol
a ganglioside GM3 (d18:1(4E))Reach from here →
1. beta-N-acetylhexosaminidase (GM2)
Catalysed by HEXA, HEXB, HEXDcytosolOne of 4 routes
a ganglioside GM1 (d18:1(4E))Reach from here →
1. beta-1,3-galactosyltransferase (GM2)
Catalysed by B3GALT4cytosolOne of 3 routes
a ganglioside GD2 (d18:1(4E))Reach from here →
1. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by ST8SIA1cytosol

Two steps

pyruvateReach from here →
1. exo-alpha-sialidase (GM2)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol
aldehydo-N-acetyl-D-mannosamineReach from here →
1. exo-alpha-sialidase (GM2)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol

Three steps

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))Reach from here →

Catalysed by HEXA, HEXB, HEXD, NEU4 and 3 morecytosolOne of 4 routes

a ganglioside GA1 (d18:1(4E))Reach from here →

Catalysed by B3GALT4, NEU3cytosolOne of 2 routes

alpha-D-galactoseReach from here →

Catalysed by B3GALT4, LCT, GLB1, GLB1L and 1 morecytosolOne of 4 routes

N-glycoloylneuraminateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2cytosol

CMP-N-acetyl-beta-neuraminateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol, nucleusOne of 2 routes

a ganglioside GD3 (d18:1(4E))Reach from here →

Catalysed by HEXA, HEXB, HEXD, ST8SIA1cytosolOne of 5 routes

a ganglioside GD1a (d18:1(4E))Reach from here →

Catalysed by B3GALT4, ST3GAL1, ST3GAL4, ST3GAL2cytosolOne of 3 routes

a ganglioside Fuc-GM1 (d18:1(4E))Reach from here →

Catalysed by B3GALT4, FUT2cytosol

a ganglioside GD1b (d18:1(4E))Reach from here →

Catalysed by B3GALT4, ST8SIA1cytosolOne of 4 routes

Catalysed by NEU4, NEU1, NEU3, NEU2 and 7 more

cytosol, extracellular space

One of 2 routes

an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 4 morecytosol, nucleus

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus

acetoacetateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol, mitochondrial matrixOne of 4 routes

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 4 morecytosol, nucleus

an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus

a globoside MSGGReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus

a globoside DSGGReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus

a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus

a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer(d18:1(4E))Reach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus

an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc derivativeReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus

acetylpyruvateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol

all-trans-retinoic acidReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 7 morecytosol, extracellular spaceOne of 2 routes

(S)-malateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosolOne of 2 routes

N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamineReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, mitochondrial matrix

oxaloacetateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, mitochondrial matrixOne of 3 routes

(S)-lactateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 6 morecytosol

2-oxobutanoateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol

2-oxoglutaramateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosolOne of 2 routes

galactitolReach from here →

Catalysed by B3GALT4, LCT, GLB1, GLB1L and 2 morecytosol

3-fumarylpyruvateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol

(R)-3-hydroxybutyric acidReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 7 morecytosol, extracellular spaceOne of 2 routes

a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))Reach from here →

Catalysed by HEXA, HEXB, HEXD, NEU4 and 4 morecytosolOne of 3 routes

3-hydroxypyruvateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol

aceneuramateReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosolOne of 2 routes

5'-deoxyadenosineReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol

dTDPReach from here →

Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol

a globoside Gb3Cer (d18:1(4E))Reach from here →

Catalysed by HEXA, HEXB, HEXD, NEU4 and 4 morecytosolOne of 3 routes

D-glucosyl-N-acylsphingosineReach from here →

Catalysed by HEXA, HEXB, HEXD, NEU4 and 7 morecytosol, lysosome