Compound

a ganglioside GM1 (d18:1(4E))

A carbohydrate acid derivative anion obtained by deprotonation of the carboxy group on the Neu5Ac residue of β-D-Gal-(1→3)-β-D-GalNAc-(1→4)-[α-Neu5Ac-(2→3)]-β-D-Gal-(1→4)-β-D-Glc-(1↔1')-Cer. It is the major species at pH 7.3.

Definition from ChEBI (CHEBI:77709), read 2026-09-23. CC BY 4.0.

CHEBI:77709ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound, anion
Formula: C56H95N3O31R
Mass: 1306.357 g/mol
Charge: -1
SMILES: *C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@H]3NC(C)=O)[C@H](O[C@]3(C(=O)[O-])C[C@H](O)[C@@H](NC(C)=O)[C@]([H])([C@H](O)[C@H](O)CO)O3)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)/C=C/CCCCCCCCCCCCC
Look it up: ChEBI

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

15 entities

15 entities reached.

0 reported hops15 assembled from the scaffold

Show the remaining 3

What the reference databases state

Statements

28 statements

28 statements · 2 reference databases · Subject: a ganglioside GM1 (d18:1(4E)) · Sources: Human-GEM, Rhea

Order

a ganglioside GM1 (d18:1(4E)) is a substrate of CTSAProteinHuman-GEM MAR12036Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of FUT2ProteinRhea RHEA:42040Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of GALNSProteinHuman-GEM MAR12036Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of GLB1ProteinHuman-GEM MAR00830Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of GLB1ProteinHuman-GEM MAR12036Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of GLB1ProteinHuman-GEM MAR02341Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of GLB1ProteinHuman-GEM MAR00832Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of GLB1LProteinHuman-GEM MAR00830Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of GLB1LProteinHuman-GEM MAR00832Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of GM2AProteinHuman-GEM MAR12036Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of LCTProteinHuman-GEM MAR00832Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of LCTProteinHuman-GEM MAR00830Inferred only

Show the remaining 16

a ganglioside GM1 (d18:1(4E)) is a substrate of NEU1ProteinHuman-GEM MAR12036Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of NEU2ProteinHuman-GEM MAR12068Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of NEU3ProteinRhea RHEA:48072Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of PSAPProteinHuman-GEM MAR12036Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of ST3GAL1ProteinHuman-GEM MAR08188Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of ST3GAL1ProteinHuman-GEM MAR00837Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of ST3GAL1ProteinRhea RHEA:18021Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of ST3GAL2ProteinHuman-GEM MAR08188Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of ST3GAL2ProteinHuman-GEM MAR00837Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of ST3GAL2ProteinRhea RHEA:18021Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of ST3GAL4ProteinRhea RHEA:18021Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of ST3GAL4ProteinHuman-GEM MAR00837Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of ST3GAL4ProteinHuman-GEM MAR08188Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of ST8SIA1ProteinHuman-GEM MAR00852Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of TMPPEProteinHuman-GEM MAR00830Inferred only
a ganglioside GM1 (d18:1(4E)) is a substrate of TMPPEProteinHuman-GEM MAR00832Inferred only

Reactions

33 reactions

CMP-N-acetyl-beta-neuraminate+MAM01904ccytidine 5'-monophosphate+a ganglioside GM1 (d18:1(4E))+proton
Catalysed by ST3GAL5
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.9cytosol
Human-GEM MAR00820CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+CHEBI:67119a ganglioside GM1 (d18:1(4E))+proton+UDP
Catalysed by B3GALT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.62cytosol
Human-GEM MAR00829CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+wateralpha-D-galactose+a ganglioside GM2 (d18:1(4E))
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23cytosol
Human-GEM MAR00830CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))a ganglioside GM1 (d18:1(4E))
Reaction pageReversibleBalance undeterminablecytosol, lysosome
Human-GEM MAR00831CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+wateralpha-D-galactose+a ganglioside GM2 (d18:1(4E))
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23lysosome
Human-GEM MAR00832CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM1 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD1a (d18:1(4E))+proton
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4cytosol
Human-GEM MAR00837CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+watera ganglioside GM1 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00838CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM1 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD1b (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8cytosol
Human-GEM MAR00852CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR01975CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+wateralpha-D-galactose+a ganglioside GM2 (d18:1(4E))
Catalysed by GLB1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23extracellular space
Human-GEM MAR02341CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+CHEBI:67119a ganglioside GM1 (d18:1(4E))+proton+UDP
Catalysed by B3GALT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.62Golgi apparatus
Human-GEM MAR08185CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM1 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD1a (d18:1(4E))+proton
Catalysed by ST3GAL1 or ST3GAL4 or ST3GAL2
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.4Golgi apparatus
Human-GEM MAR08188CC BY 4.0Reference data

Show the remaining 21

Other names

4 names

Resolves to: a ganglioside GM1 (d18:1(4E))

Also called: beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(11')-Cer(1-)Ganglioside GM1 (d18:1(4E))GM1(d18:1(4E))β-D-Gal-(1→3)-β-D-GalNAc-(1→4)-[α-Neu5Ac-(2→3)]-β-D-Gal-(1→4)-β-D-Glc-(1↔1')-Cer(1−)