a ganglioside GD2 (d18:1(4E))

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

215 compounds within 3 steps: 4 in 1, 14 in 2, 197 in 3

One step

N-acetyl-beta-neuraminic acidReach from here →
1. Sialidase, Plasma Membrane (Neu3)
Catalysed by NEU3extracellular space
a ganglioside GM2 (d18:1(4E))Reach from here →
1. Sialidase, Plasma Membrane (Neu3)
Catalysed by NEU3extracellular space
a ganglioside GD3 (d18:1(4E))Reach from here →
1. Hexosaminidase A, Lysosomal
Catalysed by HEXA, HEXBlysosome
a ganglioside GD1b (d18:1(4E))Reach from here →
1. beta-1,3-galactosyltransferase (GD2)
Catalysed by B3GALT4cytosolOne of 3 routes

Two steps

CHEBI:1146900Reach from here →
1. Hexosaminidase A, Lysosomal
2. solute carrier (acetyl-CoA)
Catalysed by HEXA, HEXB, SLC33A1lysosome, cytosolOne of 2 routes
pyruvateReach from here →
1. Sialidase, Plasma Membrane (Neu3)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by NEU3, NPLextracellular space, cytosol
aldehydo-N-acetyl-D-mannosamineReach from here →

Three steps

(S)-carnitineReach from here →
Catalysed by HEXA, HEXB, SLC33A1, CPT1A and 2 morelysosome, cytosolOne of 244 routes
2-hydroxybutyric acidReach from here →

Catalysed by NEU3, NPLextracellular space, cytosol

a ganglioside Ac-O-7-GD3(d18:1(4E))Reach from here →

Catalysed by HEXA, HEXB, CASD1lysosome

a ganglioside GA2 (d18:1(4E))Reach from here →

Catalysed by NEU3, NEU4, NEU1, NEU2extracellular space, cytosolOne of 2 routes

alpha-D-galactoseReach from here →

Catalysed by B3GALT4, GLB1cytosol, lysosome

N-acetyl-beta-D-galactosamineReach from here →

Catalysed by NEU3, HEXA, HEXBextracellular space

N-glycoloylneuraminateReach from here →

Catalysed by NEU3extracellular space, cytosol

N-acetylneuraminateReach from here →

Catalysed by B3GALT4, NEU3cytosolOne of 3 routes

CMP-N-acetyl-beta-neuraminateReach from here →

Catalysed by NEU3, CMASextracellular space, nucleusOne of 2 routes

a ganglioside GM3 (d18:1(4E))Reach from here →

Catalysed by HEXA, HEXB, NEU3lysosome, extracellular spaceOne of 6 routes

a ganglioside GM1 (d18:1(4E))Reach from here →

Catalysed by B3GALT4, NEU2cytosolOne of 6 routes

a ganglioside GT3 (d18:1(4E))Reach from here →

Catalysed by HEXA, HEXB, ST8SIA5, ST8SIA1lysosome, cytosolOne of 3 routes

a ganglioside GT1b (d18:1(4E))Reach from here →

Catalysed by B3GALT4, ST3GAL1, ST3GAL4, ST3GAL2cytosolOne of 3 routes

Catalysed by NEU3, NPL, SLC16A4, SLC16A5 and 4 more

extracellular space, cytosol

One of 2 routes

an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivativeReach from here →

Catalysed by NEU3, CMAS, ST6GAL1, ST6GAL2extracellular space, nucleus

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivativeReach from here →

Catalysed by NEU3, CMAS, ST3GAL3, ST3GAL4 and 1 moreextracellular space, nucleus

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivativeReach from here →

Catalysed by NEU3, CMAS, ST3GAL4extracellular space, nucleus

acetoacetateReach from here →

Catalysed by NEU3, NPLextracellular space, cytosol, mitochondrial matrixOne of 4 routes

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivativeReach from here →

Catalysed by NEU3, CMAS, ST3GAL1, ST3GAL4 and 1 moreextracellular space, nucleus

an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivativeReach from here →

Catalysed by NEU3, CMAS, ST8SIA3, ST8SIA1extracellular space, nucleus

a globoside MSGGReach from here →

Catalysed by NEU3, CMAS, ST3GAL2extracellular space, nucleus

a globoside DSGGReach from here →

Catalysed by NEU3, CMAS, ST6GALNAC3, ST6GALNAC6extracellular space, nucleus

a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivativeReach from here →

Catalysed by NEU3, CMAS, ST6GALNAC1, ST6GALNAC2extracellular space, nucleus

a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer(d18:1(4E))Reach from here →

Catalysed by NEU3, CMAS, ST3GAL6extracellular space, nucleus

an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc derivativeReach from here →

Catalysed by NEU3, CMAS, ST6GALNAC3, ST6GALNAC4extracellular space, nucleus

(7Z)-octadecenoyl-CoAReach from here →

Catalysed by HEXA, HEXB, SLC33A1, CPT1A and 2 morelysosome, cytosolOne of 3 routes

CHEBI:15345Reach from here →

Catalysed by HEXA, HEXB, SLC33A1, AACSlysosome, cytosolOne of 2 routes

cholineReach from here →

Catalysed by HEXA, HEXB, SLC33A1, CHATlysosome, cytosol, nucleus

acetylpyruvateReach from here →

Catalysed by NEU3, NPL, FAHD1extracellular space, cytosol

all-trans-retinoic acidReach from here →

Catalysed by NEU3, NPL, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosolOne of 2 routes

CHEBI:15380Reach from here →

Catalysed by HEXA, HEXB, SLC33A1, ALAS1 and 1 morelysosome, cytosol, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

Catalysed by HEXA, HEXB, SLC33A1, GLYAT and 2 morelysosome, cytosol, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

Catalysed by HEXA, HEXB, SLC33A1, CPT1A and 1 morelysosome, cytosolOne of 2 routes

isobutyryl-CoAReach from here →

Catalysed by HEXA, HEXB, SLC33A1, HADHA and 2 morelysosome, cytosol, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

Catalysed by HEXA, HEXB, SLC33A1, GLYATlysosome, cytosol, mitochondrial matrix

isovaleryl-CoAReach from here →

Catalysed by HEXA, HEXB, SLC33A1, GLYAT and 2 morelysosome, cytosol, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

Catalysed by HEXA, HEXB, SLC33A1, SLC27A2 and 7 morelysosome, cytosolOne of 11 routes

CHEBI:15519Reach from here →

Catalysed by HEXA, HEXB, SLC33A1, ACAA1 and 2 morelysosome, cytosol, peroxisomeOne of 2 routes

palmitoyl-CoAReach from here →

Catalysed by HEXA, HEXB, SLC33A1, SLC27A2 and 7 morelysosome, cytosolOne of 11 routes

oleoyl-CoAReach from here →

Catalysed by HEXA, HEXB, SLC33A1, CPT1A and 2 morelysosome, cytosolOne of 11 routes

phenylacetyl-CoAReach from here →

Catalysed by HEXA, HEXB, SLC33A1lysosome, cytosolOne of 3 routes

propionyl-CoAReach from here →

Catalysed by HEXA, HEXB, SLC33A1, ACSS3 and 2 morelysosome, cytosolOne of 43 routes

(S)-malateReach from here →

Catalysed by NEU3, NPL, ME2extracellular space, cytosolOne of 2 routes

N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamineReach from here →

Catalysed by NEU3, CMAS, ST6GALNAC4extracellular space, nucleus