Compound

a ganglioside GM2 (d18:1(4E))

An N-acetylneuraminate that is the conjugate base of β-D-GalNAc-(1→4)-[α-Neu5Ac-(2→3)]-β-D-Gal-(1→4)-β-D-Glc-(1↔1')-Cer, obtained by deprotonation of the carboxy group; major species at pH 7.3.

Definition from ChEBI (CHEBI:71502), read 2026-09-23. CC BY 4.0.

CHEBI:71502ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound, anion
Formula: C50H85N3O26R
Mass: 1144.214 g/mol
Charge: -1
SMILES: *C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3NC(C)=O)[C@H](O[C@]3(C(=O)[O-])C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O3)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)/C=C/CCCCCCCCCCCCC
Look it up: ChEBI

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

10 entities

10 entities reached.

0 reported hops10 assembled from the scaffold

What the reference databases state

Statements

22 statements

22 statements · 2 reference databases · Subject: a ganglioside GM2 (d18:1(4E)) · Sources: Human-GEM, Rhea

Order

a ganglioside GM2 (d18:1(4E)) is a substrate of B3GALT4ProteinHuman-GEM MAR08185Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of B3GALT4ProteinRhea RHEA:16773Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of B3GALT4ProteinHuman-GEM MAR00829Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of GM2AProteinHuman-GEM MAR12061Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of GM2AProteinHuman-GEM MAR12063Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of GM2AProteinHuman-GEM MAR00835Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of HEXAProteinHuman-GEM MAR12061Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of HEXAProteinHuman-GEM MAR00828Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of HEXAProteinHuman-GEM MAR12063Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of HEXAProteinRhea RHEA:47940Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of HEXBProteinHuman-GEM MAR12063Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of HEXBProteinRhea RHEA:47940Inferred only

Show the remaining 10

a ganglioside GM2 (d18:1(4E)) is a substrate of HEXBProteinHuman-GEM MAR12061Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of HEXBProteinHuman-GEM MAR00828Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of HEXDProteinHuman-GEM MAR00828Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of NEU1ProteinHuman-GEM MAR00850Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of NEU2ProteinHuman-GEM MAR00850Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of NEU3ProteinRhea RHEA:48068Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of NEU3ProteinHuman-GEM MAR00850Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of NEU4ProteinRhea RHEA:48068Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of NEU4ProteinHuman-GEM MAR00850Inferred only
a ganglioside GM2 (d18:1(4E)) is a substrate of ST8SIA1ProteinHuman-GEM MAR00851Inferred only

Reactions

25 reactions

a ganglioside GM3 (d18:1(4E))+MAM03110ca ganglioside GM2 (d18:1(4E))+proton+UDP
Catalysed by B4GALNT1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.92cytosol
Human-GEM MAR00827CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GM3 (d18:1(4E))+MAM02525c
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00828CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+CHEBI:67119a ganglioside GM1 (d18:1(4E))+proton+UDP
Catalysed by B3GALT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.62cytosol
Human-GEM MAR00829CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+wateralpha-D-galactose+a ganglioside GM2 (d18:1(4E))
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23cytosol
Human-GEM MAR00830CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+wateralpha-D-galactose+a ganglioside GM2 (d18:1(4E))
Catalysed by LCT & GLB1 & GLB1L & TMPPE
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23lysosome
Human-GEM MAR00832CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+MAM02012lMAM02013l
Catalysed by GM2A
Reaction pageLeft to rightBalance undeterminablelysosome
Human-GEM MAR00835CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GA2 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GM2 (d18:1(4E))+proton
Catalysed by ST6GALNAC2 or ST3GAL5
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.9cytosol
Human-GEM MAR00849CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GA2 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18cytosol
Human-GEM MAR00850CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM2 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD2 (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8cytosol
Human-GEM MAR00851CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR01972CC BY 4.0Reference data
a ganglioside GM1 (d18:1(4E))+wateralpha-D-galactose+a ganglioside GM2 (d18:1(4E))
Catalysed by GLB1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23extracellular space
Human-GEM MAR02341CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+CHEBI:67119a ganglioside GM1 (d18:1(4E))+proton+UDP
Catalysed by B3GALT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.62Golgi apparatus
Human-GEM MAR08185CC BY 4.0Reference data

Show the remaining 13

Other names

6 names

Resolves to: a ganglioside GM2 (d18:1(4E))

Also called: GalNAcbeta1-4(NeuAcalpha2-3)Galbeta1-4Glcbeta-CerGanglioside GM2 (d18:1(4E))GM2GM2(d18:1(4E))N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide anionN-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminosyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosylceramide anion