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Proteins/UNIPROT:Q969X2
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity)..
Function from UniProtKB (Q969X2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
83 statements
83 statements · 6 reference databases · Subject: ST6GALNAC6 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
13 reactions
CMP-N-acetyl-beta-neuraminate+MAM02010ccytidine 5'-monophosphate+a ganglioside GD1a (d18:1(4E))+proton
Catalysed by ST6GALNAC5 or ST6GALNAC4 or ST6GALNAC6 or ST6GALNAC3
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-, 2.4.3.7cytosol
Human-GEM MAR00823CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1a (d18:1(4E))cytidine 5'-monophosphate
7 names
Resolves to: ST6GALNAC6
Catalysed by ST6GALNAC6
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-cytosol
Human-GEM MAR00840CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GT1b (d18:1(4E))cytidine 5'-monophosphate+MAM02024c+proton
Catalysed by ST6GALNAC6
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-cytosol
Human-GEM MAR00848CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02010gcytidine 5'-monophosphate+MAM01942g+proton
Catalysed by ST6GALNAC5 or ST6GALNAC4 or ST6GALNAC6 or ST6GALNAC3
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-, 2.4.3.7Golgi apparatus
Human-GEM MAR08168CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GD1a (d18:1(4E))cytidine 5'-monophosphate+MAM02029g+proton
Catalysed by ST6GALNAC6
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08175CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GT1b (d18:1(4E))cytidine 5'-monophosphate+MAM02024g+proton
Catalysed by ST6GALNAC6
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-Golgi apparatus
Human-GEM MAR08178CC BY 4.0Reference data
a ganglioside GM1b (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GD1alpha (d18:1(4E))+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC6 or ST6GALNAC5 or ST6GALNAC4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41968CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GT1aalpha (d18:1(4E))+CMP+hydron
Catalysed by ST6GALNAC6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41972CC BY 4.0Reference data
a ganglioside GT1b (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GQ1balpha (d18:1(4E))+CMP+hydron
Catalysed by ST6GALNAC6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41976CC BY 4.0Reference data
N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine+CMP-N-acetyl-beta-neuraminateN-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine+CMP+hydron
Catalysed by ST6GALNAC6 or ST6GALNAC5
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47884CC BY 4.0Reference data
a globoside MSGG+CMP-N-acetyl-beta-neuraminatea globoside DSGG+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56088CC BY 4.0Reference data
3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-seryl-[protein]+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC6 or ST6GALNAC4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:65280CC BY 4.0Reference data