Loading the page.
Proteins/UNIPROT:Q9NSC7
Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis. Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins. Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells, as well as ulcerative colitis (UC) and various cancers. Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation..
Function from UniProtKB (Q9NSC7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
43 statements
43 statements · 7 reference databases · Subject: ST6GALNAC1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
CMP-N-acetyl-beta-neuraminate+MAM02906gcytidine 5'-monophosphate+MAM01712g+proton
Catalysed by ST6GALNAC1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.3Golgi apparatus
Human-GEM MAR07172CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM03000gcytidine 5'-monophosphate+proton+MAM02907g
Catalysed by ST6GALNAC1
8 names
Resolves to: ST6GALNAC1
Human-GEM MAR07183CC BY 4.0Reference data
a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative+CMP-N-acetyl-beta-neuraminatea beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative+CMP+hydron
Catalysed by ST6GALNAC1 or ST6GALNAC2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11136CC BY 4.0Reference data
a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+CMP+hydron
Catalysed by ST6GALNAC1 or ST6GALNAC2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:81643CC BY 4.0Reference data
a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]+CMP+hydron
Catalysed by ST6GALNAC1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:81647CC BY 4.0Reference data
a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]+CMP+hydron
Catalysed by ST6GALNAC1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:81651CC BY 4.0Reference data
a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein]+CMP+hydron
Catalysed by ST6GALNAC1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:81655CC BY 4.0Reference data
a 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-threonyl-[protein]+CMP+hydron
Catalysed by ST6GALNAC1 or ST6GALNAC2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:81659CC BY 4.0Reference data