Compound

a ganglioside GD2 (d18:1(4E))

An anionic ganglioside obtained by deprotonation of the neuraminosyl carboxy groups of β-GalNAc-(1→4)-[α-Neu5Ac-(2→8)-α-Neu5Ac-(2→3)]-β-Gal-(1→4)-β-Glc-(1↔1')-Cer; major species at pH 7.3.

Definition from ChEBI (CHEBI:78542), read 2026-09-23. CC BY 4.0.

CHEBI:78542ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound, anion
Formula: C61H101N4O34R
Mass: 1434.463 g/mol
Charge: -2
SMILES: *C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3NC(C)=O)[C@H](O[C@]3(C(=O)[O-])C[C@H](O)[C@@H](NC(C)=O)[C@]([H])([C@H](O)[C@@H](CO)O[C@]4(C(=O)[O-])C[C@H](O)[C@@H](NC(C)=O)[C@]([H])([C@H](O)[C@H](O)CO)O4)O3)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)/C=C/CCCCCCCCCCCCC
Look it up: ChEBI

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

5 entities

5 entities reached.

0 reported hops5 assembled from the scaffold

What the reference databases state

Statements

7 statements

7 statements · 2 reference databases · Subject: a ganglioside GD2 (d18:1(4E)) · Sources: Human-GEM, Rhea

Order

a ganglioside GD2 (d18:1(4E)) is a substrate of B3GALT4ProteinHuman-GEM MAR08186Inferred only
a ganglioside GD2 (d18:1(4E)) is a substrate of B3GALT4ProteinRhea RHEA:47568Inferred only
a ganglioside GD2 (d18:1(4E)) is a substrate of B3GALT4ProteinHuman-GEM MAR00843Inferred only
a ganglioside GD2 (d18:1(4E)) is a substrate of B4GALNT1ProteinRhea RHEA:41816Inferred only
a ganglioside GD2 (d18:1(4E)) is a substrate of HEXAProteinHuman-GEM MAR12062Inferred only
a ganglioside GD2 (d18:1(4E)) is a substrate of HEXBProteinHuman-GEM MAR12062Inferred only
a ganglioside GD2 (d18:1(4E)) is a substrate of NEU3ProteinHuman-GEM MAR12076Inferred only

Reactions

12 reactions

a ganglioside GD3 (d18:1(4E))+MAM03110ca ganglioside GD2 (d18:1(4E))+proton+UDP
Catalysed by B4GALNT1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.92GO:0005829
Human-GEM MAR00842CC BY 4.0Reference data
a ganglioside GD2 (d18:1(4E))+CHEBI:67119a ganglioside GD1b (d18:1(4E))+proton+UDP
Catalysed by B3GALT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.62GO:0005829
Human-GEM MAR00843CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+a ganglioside GM2 (d18:1(4E))cytidine 5'-monophosphate+a ganglioside GD2 (d18:1(4E))+proton
Catalysed by ST8SIA1
Reaction pageLeft to rightBalance undeterminableEC 2.4.3.8GO:0005829
Human-GEM MAR00851CC BY 4.0Reference data
a ganglioside GD2 (d18:1(4E))+CHEBI:67119a ganglioside GD1b (d18:1(4E))+proton+UDP
Catalysed by B3GALT4
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.62GO:0005794
Human-GEM MAR08186CC BY 4.0Reference data
a ganglioside GD3 (d18:1(4E))+MAM03110ga ganglioside GD2 (d18:1(4E))+proton+UDP
Catalysed by B4GALNT1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.92GO:0005794
Human-GEM MAR08191CC BY 4.0Reference data
a ganglioside GD1b (d18:1(4E))+wateralpha-D-galactose+a ganglioside GD2 (d18:1(4E))
Catalysed by GLB1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.23GO:0005764
Human-GEM MAR12038CC BY 4.0Reference data
a ganglioside GD2 (d18:1(4E))+watera ganglioside GD3 (d18:1(4E))+MAM02525l
Catalysed by HEXA & HEXB
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52GO:0005764
Human-GEM MAR12062CC BY 4.0Reference data
a ganglioside GD2 (d18:1(4E))+watera ganglioside GM2 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU3
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18GO:0005615
Human-GEM MAR12076CC BY 4.0Reference data
a ganglioside GD2 (d18:1(4E))
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR12105CC BY 4.0Reference data
a ganglioside GD3 (d18:1(4E))+UDP-N-acetyl-alpha-D-galactosaminea ganglioside GD2 (d18:1(4E))+UDP+hydron
Catalysed by B4GALNT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41816CC BY 4.0Reference data
a ganglioside GD2 (d18:1(4E))+UDP-alpha-D-galactosea ganglioside GD1b (d18:1(4E))+UDP+hydron
Catalysed by B3GALT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47568CC BY 4.0Reference data
a ganglioside GD2 (d18:1(4E))+acetyl-CoACHEBI:230524+coenzyme A(4-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:79711CC BY 4.0Reference data

Other names

8 names

Resolves to: a ganglioside GD2 (d18:1(4E))

Also called: Ganglioside GD2 (d18:1(4E))GD2(d18:1(4E))N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramideN-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-N-acylsphing-4-enineN-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-N-acylsphingosineN-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminyl-(2→8)-α-N-acetylneuraminyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramideN-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminyl-(2→8)-α-N-acetylneuraminyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-N-acylsphing-4-enineN-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminyl-(2→8)-α-N-acetylneuraminyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-N-acylsphingosine