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Proteins/UNIPROT:Q8NDV1
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity..
Function from UniProtKB (Q8NDV1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
41 statements
41 statements · 5 reference databases · Subject: ST6GALNAC3 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
CMP-N-acetyl-beta-neuraminate+MAM02010ccytidine 5'-monophosphate+a ganglioside GD1a (d18:1(4E))+proton
Catalysed by ST6GALNAC5 or ST6GALNAC4 or ST6GALNAC6 or ST6GALNAC3
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-, 2.4.3.7cytosol
Human-GEM MAR00823CC BY 4.0Reference data
CMP-N-acetyl-beta-neuraminate+MAM02010gcytidine 5'-monophosphate
7 names
Resolves to: ST6GALNAC3
Catalysed by ST6GALNAC5 or ST6GALNAC4 or ST6GALNAC6 or ST6GALNAC3
Reaction pageLeft to rightBalance undeterminableEC 2.4.99.-, 2.4.3.7Golgi apparatus
Human-GEM MAR08168CC BY 4.0Reference data
a ganglioside GM1b (d18:1(4E))+CMP-N-acetyl-beta-neuraminatea ganglioside GD1alpha (d18:1(4E))+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC6 or ST6GALNAC5 or ST6GALNAC4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41968CC BY 4.0Reference data
an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative+CMP-N-acetyl-beta-neuraminatean alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc derivative+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:53896CC BY 4.0Reference data
a globoside MSGG+CMP-N-acetyl-beta-neuraminatea globoside DSGG+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56088CC BY 4.0Reference data
3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-seryl-[protein]+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC6 or ST6GALNAC4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:65280CC BY 4.0Reference data
3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein]+CMP-N-acetyl-beta-neuraminatea 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-threonyl-[protein]+CMP+hydron
Catalysed by ST6GALNAC3 or ST6GALNAC6 or ST6GALNAC4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:65284CC BY 4.0Reference data