3-iodo-L-tyrosine

Three steps

• 5-aminolevulinateReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by IYD, AADAT, ALAS1, ALAS2

• chenodeoxycholateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• glycochenodeoxycholateReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by IYD, AADAT, BAAT

• taurocholateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• glycochenodeoxycholic acidReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by IYD, AADAT, BAATperoxisomeOne of 3 routes

• glyoxylateReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by IYD, TAT, AADATOne of 12 routes

• glycolithocholic acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 6 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by IYD, AADAT, GCATmitochondrial matrix

• (R)-lactic acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• (S)-lactic acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by TPO, SDS, SDSL, SRR and 2 morecytosol, mitochondrial matrixOne of 5 routes

• (6R)-L-erythro-6,7-dihydrobiopterinReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
  3. (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by IYD, TH, PCBD1, PCBD2One of 2 routes

• 2-iminopropanoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• phosphoenolpyruvic acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. pyruvate kinase (dTDP)

  Catalysed by TPO, SDS, SDSL, SRR and 2 morecytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• L-ornithineReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. transport of ornithine and phenylalanine (cytosol to extracellular)

  Catalysed by IYD, PAH, SLC7A6extracellular space, cytosolOne of 7 routes

• gamma-Glu-AlaReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by TPO, SLCO1A2, SLCO1B3, GGT1 and 5 morecytosol, extracellular space

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by IYD, AADAT, GLDC, GCSHmitochondrial matrix

• taurineReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by TPO, SLC26A4, SLC6A6cytosol, extracellular spaceOne of 2 routes

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by TPO, DIO1, DIO3cytosol

• a 3-acylpyruvateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• prostaglandin E1Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO2A1cytosol, extracellular spaceOne of 4 routes

• prostaglandin I2Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO2A1cytosol, extracellular spaceOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO2A1cytosol, extracellular spaceOne of 4 routes

• prostaglandin H2Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO2A1cytosol, extracellular spaceOne of 4 routes

• prostaglandin D2Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO2A1cytosol, extracellular spaceOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by TPO, SLCO1A2, SLCO1B3, GPX5 and 8 morecytosol, extracellular space

• sarcosineReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by IYD, AADAT, PIPOXOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by TPO, DIO1, DIO3, MTO1cytosol

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by IYD, AADAT, SHMT1, SHMT2

• leukotriene A4Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO2A1cytosol, extracellular spaceOne of 4 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. L-Citrulline:L-aspartate ligase (AMP-forming)

  Catalysed by IYD, SLC7A13, ASS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (R)-S-lactoylglutathioneReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by TPO, SLCO1A2, SLCO1B3, GLO1 and 1 morecytosol, extracellular spaceOne of 2 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. IMP:L-aspartate ligase (GDP-forming)

  Catalysed by IYD, SLC7A13, ADSS2, ADSS1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• L-histidineReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

  Catalysed by IYD, PAH, SLC7A8inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylglycineReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by IYD, AADAT, GLYATL3, GLYAT and 1 more

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• S-formylglutathioneReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by TPO, SLCO1A2, SLCO1B3, ADH1C and 5 morecytosol, extracellular space

• 2-methyl-3-oxopropanoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• guanidinoacetateReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by TPO, SLC26A4cytosol, extracellular spaceOne of 3 routes

• L-methionineReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and methionine (cytosol to extracellular)

  Catalysed by TPO, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 16 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• L-tryptophanReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by TPO, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 16 routes

• glutathioneReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by IYD, AADAT, GSS

• L-kynurenineReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. Transport of L-Kynurenine

  Catalysed by IYD, PAH, SLC7A8extracellular space, cytosolOne of 2 routes

• beta-alanineReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by TPO, SLC26A4, SLC6A6, SLC6A14cytosol, extracellular spaceOne of 4 routes

• L-alanineReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by TPO, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 33 routes

• leukotriene C4Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. leukotriene C4 synthase (GSH)

  Catalysed by TPO, SLCO1A2, SLCO1B3, LTC4Scytosol, extracellular spaceOne of 7 routes

• L-asparagineReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by TPO, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 11 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by IYD, SLC7A13, AGAinner side of the membrane, outer side of the membrane

• glutathione disulfideReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by TPO, SLCO1A2, SLCO1B3, GPX5 and 8 morecytosol, extracellular spaceOne of 13 routes