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Proteins/UNIPROT:Q6PHW0
Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways. Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine..
Function from UniProtKB (Q6PHW0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
18 statements
18 statements · 7 reference databases · Subject: IYD · Sources: Bgee, Hetionet, Human Protein Atlas, Reactome, Rhea, UniProt, WikiPathways
5 reactions
iodide+L-tyrosine+NADP(3-)3-iodo-L-tyrosine+NADPH(4-)
Catalysed by IYD
Reaction pageRight to leftBalanced
Rhea RHEA:27453CC BY 4.0Reference data
3-iodo-L-tyrosine+iodide+NADP(3-)3,5-diiodo-L-tyrosine+NADPH(4-)+hydron
Catalysed by IYD
4 names
Resolves to: IYD
Rhea RHEA:27457CC BY 4.0Reference data
2iodide+L-tyrosine+2NADP(3-)3,5-diiodo-L-tyrosine+2NADPH(4-)+hydron
Catalysed by IYD
Reaction pageRight to leftBalanced
Rhea RHEA:32479CC BY 4.0Reference data
L-tyrosine+chloride+NADP(3-)3-chloro-L-tyrosine+NADPH(4-)
Catalysed by IYD
Reaction pageRight to leftBalanced
Rhea RHEA:70343CC BY 4.0Reference data
bromide+L-tyrosine+NADP(3-)3-bromo-L-tyrosine+NADPH(4-)
Catalysed by IYD
Reaction pageRight to leftBalanced
Rhea RHEA:70347CC BY 4.0Reference data