S-sulfanylglutathione

Three steps

• acetylpyruvateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by ETHE1, MPST, TST, FAHD1mitochondrial matrix, cytosol

• all-trans-retinoic acidReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by ETHE1, MPST, TST, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• arachidonoyl-CoAReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by ETHE1, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• CHEBI:15519Reach from here →
  1. Persulfide dioxygenase
  2. solute carrier organic anion transporter (cholate)
  3. Cholate:CoA ligase (AMP-forming)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SLC27A2 and 1 moremitochondrial matrix, extracellular space, cytosol, endoplasmic reticulum

• L-leucineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and leucine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A9, SLC3A1mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• 12(S)-HPETEReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by ETHE1, ALOX12mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• 15(S)-HPETEReach from here →
  1. Persulfide dioxygenase
  2. Glutathione: 5-HPETE oxidoreductase
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by ETHE1, GPX5, GPX1, GPX2 and 6 moremitochondrial matrix, cytosolOne of 7 routes

• 5(S)-HPETEReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by ETHE1, ALOX5mitochondrial matrix, extracellular space, cytosol

• CHEBI:15699Reach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and homoserine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• formateReach from here →
  1. Persulfide dioxygenase
  2. alcohol dehydrogenase (formaldehyde)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by ETHE1, ADH1C, ADH1A, ADH5 and 4 moremitochondrial matrix, cytosol

• malonateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by ETHE1, SUOX, SLC25A14, SLC25A30 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:15971Reach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and histidine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• ferricytochrome cReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by ETHE1, SUOXmitochondrial matrix, cytosolOne of 4 routes

• (R)-lactateReach from here →
  1. Persulfide dioxygenase
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

  Catalysed by ETHE1, GLO1, GLOD4, HAGHmitochondrial matrix, cytosol

• methanethiolReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by ETHE1, TSTD1, SELENBP1

• ureaReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. Peroxidase

  Catalysed by ETHE1, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• dimethylarsinateReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by ETHE1, GSTO1, GSTO2, HEMK2

• 2-methyl-3-oxopropanoic acidReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ETHE1, MPST, TST, AGXT2mitochondrial matrix, cytosol

• L-cystineReach from here →
  1. Persulfide dioxygenase
  2. Glutathione: 5-HPETE oxidoreductase
  3. cystine to cysteine conversion

  Catalysed by ETHE1, GPX5, GPX1, GPX2 and 6 moremitochondrial matrix, cytosolOne of 5 routes

• L-citrullineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of citrulline and cysteine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• iodideReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, DIO1 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 9 routes

• ubiquinonesReach from here →
  1. Persulfide dioxygenase
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by ETHE1, SLC25A10, SDHD, SDHB and 2 moremitochondrial matrix, cytosol

• L-valineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and valine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• oxaloacetateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by ETHE1, MPST, TST, PCmitochondrial matrix, cytosolOne of 8 routes

• L-arginineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of arginine and cysteine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A6mitochondrial matrix, cytosol, extracellular spaceOne of 5 routes

• protein polypeptide chainReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. PROTEIN_BS

  Catalysed by ETHE1mitochondrial matrix, cytosol

• (S)-lactateReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SLCO2A1mitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 16 routes

• quinolinic acidReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. Transport of Quinolinic Acid

  Catalysed by ETHE1, SUOX, SLC22A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• taurochenodeoxycholate 3-sulfateReach from here →
  1. Persulfide dioxygenase
  2. solute carrier organic anion transporter (GSH)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ETHE1, SLCO1A2, SLC7A9, SLCO1B3 and 1 moremitochondrial matrix, extracellular space, cytosol

• dopamine quinoneReach from here →
  1. Persulfide dioxygenase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Peroxidase

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, MPOmitochondrial matrix, extracellular space, cytosol, lysosomeOne of 4 routes

• 2-oxobutanoateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by ETHE1, MPST, TST, AGXT2mitochondrial matrix, cytosol

• 2-oxoglutaramateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by ETHE1, MPST, TST, KYAT1mitochondrial matrix, cytosolOne of 2 routes

• formaldehydeReach from here →
  1. Persulfide dioxygenase
  2. alcohol dehydrogenase (formaldehyde)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by ETHE1, ADH1C, ADH1A, ADH5 and 3 moremitochondrial matrix, cytosol

• 3-fumarylpyruvateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by ETHE1, MPST, TST, FAHD1mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:16857Reach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and threonine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• oxalic acidReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by ETHE1, SUOX, SLC26A6mitochondrial matrix, cytosol, extracellular space

• (R)-3-hydroxybutyric acidReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by ETHE1, MPST, TST, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• (R)-lactaldehydeReach from here →
  1. Persulfide dioxygenase
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

  Catalysed by ETHE1, GLO1, GLOD4, ADH1C and 6 moremitochondrial matrix, cytosol

• 3-hydroxypyruvateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by ETHE1, MPST, TST, AGXTmitochondrial matrix, cytosol

• L-isoleucineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• CHEBI:17203Reach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• dehydroascorbic acidReach from here →
  1. Persulfide dioxygenase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, DBHmitochondrial matrix, extracellular space, cytosolOne of 19 routes

• aceneuramateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by ETHE1, MPST, TST, NPLmitochondrial matrix, cytosol

• 5'-deoxyadenosineReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by ETHE1, MPST, TST, TYW1B and 1 moremitochondrial matrix, cytosol

• enol-oxaloacetateReach from here →
  1. Persulfide dioxygenase
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by ETHE1, SLC25A10, SDHB, SDHAmitochondrial matrix, cytosol

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. aryl sulfotransferase (PAPS)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SULT1A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, SULT1A3 and 2 moremitochondrial matrix, extracellular space, cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, DIO1 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. Steryl-Sulfatase

  Catalysed by ETHE1, SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• N-acetylserotoninReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. acetyl-CoA:aralkylamine N-acetyltransferase

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, AANATmitochondrial matrix, extracellular space, cytosol