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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
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Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

Reach

N-acetylserotonin

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

2 compounds within 3 steps: 1 in 1, 1 in 2, 0 in 3

Does it reach a compound?

One step

melatoninReach from here →
1. S-adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase
Catalysed by ASMTcytosol

Two steps

CHEBI:308079Reach from here →
1. S-adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase
2. tryptase (melatonin)
Catalysed by ASMTcytosolOne of 3 routes