L-dopa

Three steps

• hypochlorous acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Peroxidase

  Catalysed by SLC7A8, SLC6A14, LPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SLC7A8, SLC6A14, SLC12A2, SLC12A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• 5,6-dihydroxyindoleReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. Peroxidase
  3. peroxidase (dopamine-O-quinone)

  Catalysed by DDC, MPO, TPO, EPX and 1 morelysosome, cytosol

• phenylacetylglycineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC7A8, SLC7A5, GLYATinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC7A8, SLC7A5, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 5(S)-HETEReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by DDC, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosolOne of 2 routes

• (2-hydroxyphenyl)acetic acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Phenylalanine Transaminase, Mitochondrial
  3. Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by SLC7A8, GOT2, TAT, HPDinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• CHEBI:28666Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of LTD4 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 5 routes

• pyridoxine 5'-phosphateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC7A8, SLC7A5, SCLYinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:28918Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. S-Adenosyl-L-methionine:phenylethanolamine N-methyltransferase

  Catalysed by DDC, DBH, PNMTcytosol

• N-acetyl-L-cysteineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC7A8, SLC7A5, NAGSinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• Cu(2+)Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O
  3. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by DDC, DBH, CYBRD1inner side of the membrane, outer side of the membrane

• L-ascorbic acidReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O
  3. a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by DDC, DBH, PAMOne of 9 routes

• K(+)Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC7A8, SLC7A5, SLC1A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• Cys-tRNA(Cys)Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, CARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, GARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A13, DARS1inner side of the membrane, outer side of the membrane, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, WARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of isoleucine and phenylalanine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, IARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, QARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• isocyanateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of citrulline and phenylalanine (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by SLC7A8, SLC7A6, LACC1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of asparagine and phenylalanine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, NARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glycocholateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 7 routes

• cholateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• hydrogen sulfideReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC7A8, SLC7A5, CTHinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC7A8, SLC7A5, IDO1, TDO2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• formic acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by SLC7A8, SLC6A14, SLC26A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• anthranilic acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Kynurenine
  3. L-Kynurenine hydrolase

  Catalysed by SLC7A8, KYNUinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• malonic acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Malonate Transport, Antiport with Chloride

  Catalysed by SLC7A8, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by SLC7A8, PM20D1inner side of the membrane, outer side of the membrane

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 5 routes

• L-lysineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of leucine and phenylalanine (cytosol to extracellular)
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by SLC7A8, SLC7A5, SLC7A7inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• D-lysineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by SLC7A8, SLC7A6, SLC25A2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• putrescineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by SLC7A8, SLC7A6, SLC3A2, SLC7A7inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by SLC7A8, SLC7A6, SLC25A2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC7A8, SLC7A13, CADinner side of the membrane, outer side of the membrane

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A8, SLC7A5, IL4I1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by SLC7A8, SLC7A5, NDUFAB1, FDXR and 5 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• serotoninReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of isoleucine and phenylalanine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC7A8, SLC7A5, BCAT2, BCAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• D-cysteineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC7A8, SLC7A5, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• D-serineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by SLC7A8, SLC7A5, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 10 routes

• 5-aminolevulinateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC7A8, SLC7A5, ALAS1, ALAS2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of isoleucine and phenylalanine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A8, SLC7A5, BCAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• chenodeoxycholateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A8, SLC7A5, GOT2, GOT1 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• glycochenodeoxycholateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC7A8, SLC7A5, BAATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• taurocholateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycochenodeoxycholic acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC7A8, SLC7A5, BAATinner side of the membrane, outer side of the membrane, extracellular space, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Phenylalanine Transaminase, Mitochondrial
  3. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine

  Catalysed by SLC7A8, GOT2, TAT, AADATinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 12 routes