What it touches on the way
Mechanistic reach
20 entities
20 entities reached.
0 reported hops20 assembled from the scaffold
- GSTP1ProteinUNIPROT:P09211metabolized byInferred only44 paths44 endpoints
- GSTA1ProteinUNIPROT:P08263metabolized byInferred only27 paths27 endpoints
- GSTM4ProteinUNIPROT:Q03013metabolized byInferred only26 paths26 endpoints
- GSTA2ProteinUNIPROT:P09210metabolized byInferred only23 paths23 endpoints
- GSTO1ProteinUNIPROT:P78417metabolized byInferred only22 paths22 endpoints
- GSTM1ProteinUNIPROT:P09488metabolized byInferred only19 paths19 endpoints
- GSTZ1ProteinUNIPROT:O43708metabolized byInferred only15 paths15 endpoints
- MGST1ProteinUNIPROT:P10620substrate ofInferred only15 paths15 endpoints
- GSTA3ProteinUNIPROT:Q16772metabolized byInferred only14 paths14 endpoints
- GSTK1ProteinUNIPROT:Q9Y2Q3metabolized byInferred only14 paths7 endpoints
- GSTM3ProteinUNIPROT:P21266metabolized byInferred only13 paths13 endpoints
- GSTM2ProteinUNIPROT:P28161metabolized byInferred only12 paths12 endpoints
Show the remaining 8
- MGST3ProteinUNIPROT:O14880substrate ofInferred only11 paths11 endpoints
- HPGDSProteinUNIPROT:O60760substrate ofInferred only11 paths11 endpoints
- MGST2ProteinUNIPROT:Q99735substrate ofInferred only10 paths10 endpoints
- GSTA4ProteinUNIPROT:O15217metabolized byInferred only9 paths9 endpoints
- GSTM5ProteinUNIPROT:P46439metabolized byInferred only9 paths9 endpoints
- GSTA5ProteinUNIPROT:Q7RTV2metabolized byInferred only9 paths9 endpoints
- GSTO2ProteinUNIPROT:Q9H4Y5metabolized byInferred only9 paths9 endpoints
- GSTT2BProteinUNIPROT:P0CG30metabolized byInferred only6 paths6 endpoints
What the reference databases state
Statements
21 statements
21 statements · 1 reference database · Subject: 5,6-dihydroxyindole · Sources: Human-GEM
- 5,6-dihydroxyindole is metabolised by GSTA1ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTA2ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTA3ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTA4ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTA5ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTK1ProteinHuman-GEM MAR03161Inferred only
- 5,6-dihydroxyindole is metabolised by GSTK1ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTM1ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTM2ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTM3ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTM4ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTM5ProteinHuman-GEM MAR06815Inferred only
Show the remaining 9
- 5,6-dihydroxyindole is metabolised by GSTO1ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTO2ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTP1ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTT2BProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is metabolised by GSTZ1ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is a substrate of HPGDSProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is a substrate of MGST1ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is a substrate of MGST2ProteinHuman-GEM MAR06815Inferred only
- 5,6-dihydroxyindole is a substrate of MGST3ProteinHuman-GEM MAR06815Inferred only
Reactions
11 reactions
5,6-dihydroxyindole+CHEBI:16856MAM01136x
Catalysed by GSTK1
Reaction pageReversibleBalancedEC 2.5.1.18GO:0005777
Human-GEM MAR03161CC BY 4.0Reference data
dopamine quinone+hydrogen peroxide5,6-dihydroxyindole+proton+2water
Catalysed by MPO or TPO or EPX or LPO
Reaction pageLeft to rightBalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2GO:0005829
Human-GEM MAR06813CC BY 4.0Reference data
MAM01333c+NADP(3-)5,6-dihydroxyindole+NADPH(4-)
Catalysed by CRYZ
Reaction pageReversibleUnbalancedEC 1.6.5.5GO:0005829
Human-GEM MAR06814CC BY 4.0Reference data
MAM01136c5,6-dihydroxyindole+CHEBI:16856
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or GSTO1 or HPGDS and 8 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18GO:0005829
Human-GEM MAR06815CC BY 4.0Reference data
5,6-dihydroxyindole+proton+NADPH(4-)MAM02361c+NADP(3-)
Catalysed by CRYZ
Reaction pageReversibleBalancedEC 1.6.5.5GO:0005829
Human-GEM MAR06817CC BY 4.0Reference data
proton+MAM02355ccarbon dioxide+5,6-dihydroxyindole
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR12012CC BY 4.0Reference data
dopaminechrome5,6-dihydroxyindole
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR12022CC BY 4.0Reference data
25,6-dihydroxyindole+dioxygen2water+2MAM03163c
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1GO:0005829
Human-GEM MAR12024CC BY 4.0Reference data
CHEBI:58782+hydron5,6-dihydroxyindole+carbon dioxide
Catalysed by DDT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18441CC BY 4.0Reference data
25,6-dihydroxyindole+dioxygen2CHEBI:27406+2water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:33515CC BY 4.0Reference data
dopaminechrome5,6-dihydroxyindole
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:70199CC BY 4.0Reference data