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Proteins/UNIPROT:P11086
Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor. Other substrates include phenylethanolamine and octopamine. Also methylates normetanephrine (By similarity)..
Function from UniProtKB (P11086), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
20 statements
20 statements · 6 reference databases · Subject: PNMT · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
5 reactions
(R)-noradrenaline+S-adenosyl-L-methionineCHEBI:28918+proton+CHEBI:16680
Catalysed by PNMT
Reaction pageLeft to rightBalancedEC 2.1.1.28cytosol
Human-GEM MAR06743CC BY 4.0Reference data
phenylethanolamine+S-adenosyl-L-methionineN-methylphenylethanolamine+S-adenosyl-L-homocysteine+hydron
Catalysed by
3 names
Resolves to: PNMT
Reaction pageLeft to rightBalanced
Rhea RHEA:12176CC BY 4.0Reference data
(R)-noradrenaline+S-adenosyl-L-methionine(R)-adrenaline+S-adenosyl-L-homocysteine+hydron
Catalysed by PNMT
Reaction pageLeft to rightBalanced
Rhea RHEA:25269CC BY 4.0Reference data
(R)-octopamine+S-adenosyl-L-methionine(R)-synephrine+S-adenosyl-L-homocysteine+hydron
Catalysed by PNMT
Reaction pageLeft to rightBalanced
Rhea RHEA:70519CC BY 4.0Reference data
(R)-normetanephrine+S-adenosyl-L-methionine(R)-metanephrine+S-adenosyl-L-homocysteine+hydron
Catalysed by PNMT
Reaction pageLeft to rightBalanced
Rhea RHEA:70683CC BY 4.0Reference data