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Proteins/UNIPROT:Q53TN4
Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes. It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood. May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity)..
Function from UniProtKB (Q53TN4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of, transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
105 statements
105 statements · 7 reference databases · Subject: CYBRD1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
CHEBI:17208+2Fe(3+)dehydroascorbic acid+2iron(2+)+2proton
Catalysed by CYBRD1
Reaction pageLeft to rightBalancedEC 1.-.-.-extracellular space
Human-GEM MAR06395CC BY 4.0Reference data
Fe(3+)+L-ascorbic acidmonodehydro-L-ascorbate radical+iron(2+)+hydron
Catalysed by
5 names
Resolves to: CYBRD1
Reaction pageLeft to rightBalanced
Rhea RHEA:30403CC BY 4.0Reference data
monodehydro-L-ascorbate radical+L-ascorbic acidmonodehydro-L-ascorbate radical+L-ascorbic acid
Transported by CYB561D2 or CYB561 or CYBRD1 or CYB561D1
Reaction pageLeft to rightBalanced
Rhea RHEA:66524CC BY 4.0Reference data
Cu(2+)+L-ascorbic acidCu(+)+monodehydro-L-ascorbate radical+hydron
Catalysed by CYBRD1
Reaction pageDirection not assertedBalanced
Rhea RHEA:66656CC BY 4.0Reference data