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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

Reach

all-trans-4-hydroxyretinoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

2 compounds within 3 steps: 2 in 1, 0 in 2, 0 in 3

Does it reach a compound?

One step

all-trans-4-oxoretinoateReach from here →
1. cytochrome P450 (4-hydroxy-all-trans-retinoate)
Catalysed by CYP26B1cytosolOne of 3 routes
all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoateReach from here →
1. all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + UDP + H(+)
Catalysed by UGT2B7