Compound

(3S)-3-hydroxybutanoyl-CoA

Tetraanion of (S)-3-hydroxybutanoyl-CoA arising from deprotonation of the phosphate and diphosphate OH groups.

Definition from ChEBI (CHEBI:57316), read 2026-09-23. CC BY 4.0.

CHEBI:57316ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C25H38N7O18P3S
Mass: 849.599 g/mol
Charge: -4
InChIKey: QHHKKMYHDBRONY-VKBDFPRVSA-J
SMILES: C[C@H](O)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

6 entities

6 entities reached.

0 reported hops6 assembled from the scaffold

What the reference databases state

Statements

18 statements

18 statements · 2 reference databases · Subject: (3S)-3-hydroxybutanoyl-CoA · Sources: Human-GEM, Rhea

Order

(2E)-butenoyl-CoA is converted to (3S)-3-hydroxybutanoyl-CoACompoundHuman-GEM MAR03164Inferred only
(2E)-butenoyl-CoA is converted to (3S)-3-hydroxybutanoyl-CoACompoundRhea RHEA:26558Inferred only
(S)-3-hydroxybutanoate is converted to (3S)-3-hydroxybutanoyl-CoACompoundRhea RHEA:65208Inferred only
(3S)-3-hydroxybutanoyl-CoA is converted to (S)-3-hydroxybutanoateCompoundRhea RHEA:65208Inferred only
(3S)-3-hydroxybutanoyl-CoA is converted to acetoacetyl-CoACompoundRhea RHEA:30799Inferred only
(3S)-3-hydroxybutanoyl-CoA is converted to acetoacetyl-CoACompoundRhea RHEA:16197Inferred only
acetoacetyl-CoA is converted to (3S)-3-hydroxybutanoyl-CoACompoundRhea RHEA:16197Inferred only
acetoacetyl-CoA is converted to (3S)-3-hydroxybutanoyl-CoACompoundRhea RHEA:30799Inferred only
(3S)-3-hydroxybutanoyl-CoA is converted to CHEBI:15345CompoundHuman-GEM MAR03166Inferred only
(3S)-3-hydroxybutanoyl-CoA is converted to CHEBI:15345CompoundHuman-GEM MAR03104Inferred only
(3S)-3-hydroxybutanoyl-CoA is a substrate of ACAA1ProteinHuman-GEM MAR03104Inferred only
(3S)-3-hydroxybutanoyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR03104Inferred only

Show the remaining 6

(3S)-3-hydroxybutanoyl-CoA is a substrate of HADHProteinRhea RHEA:30799Inferred only
(3S)-3-hydroxybutanoyl-CoA is a substrate of HADHProteinHuman-GEM MAR03166Inferred only
(3S)-3-hydroxybutanoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03166Inferred only
(3S)-3-hydroxybutanoyl-CoA is a substrate of HSD17B10ProteinRhea RHEA:30799Inferred only
(3S)-3-hydroxybutanoyl-CoA is a substrate of HSD17B10ProteinHuman-GEM MAR03166Inferred only
(3S)-3-hydroxybutanoyl-CoA is a substrate of HSD17B4ProteinHuman-GEM MAR03104Inferred only

Reactions

9 reactions

(3S)-3-hydroxybutanoyl-CoA+NAD(+)CHEBI:15345+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211peroxisome
Human-GEM MAR03104CC BY 4.0Reference data
(2E)-butenoyl-CoA+water(3S)-3-hydroxybutanoyl-CoA
Catalysed by ECHS1
Reaction pageLeft to rightBalancedEC 4.2.1.17mitochondrial matrix
Human-GEM MAR03164CC BY 4.0Reference data
(3S)-3-hydroxybutanoyl-CoA+NAD(+)CHEBI:15345+proton+NADH(2-)
Catalysed by HADHA & HADH & HSD17B10
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211mitochondrial matrix
Human-GEM MAR03166CC BY 4.0Reference data
(3S)-3-hydroxybutanoyl-CoA+NADP(3-)acetoacetyl-CoA+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:16197CC BY 4.0Reference data
(3S)-3-hydroxybutanoyl-CoACHEBI:57315
Reaction pageDirection not assertedBalanced
Rhea RHEA:21760CC BY 4.0Reference data
(3S)-3-hydroxybutanoyl-CoA(2E)-butenoyl-CoA+water
Catalysed by ECHS1
Reaction pageRight to leftBalanced
Rhea RHEA:26558CC BY 4.0Reference data
(3S)-3-hydroxybutanoyl-CoA+NAD(1-)acetoacetyl-CoA+NADH(2-)+hydron
Catalysed by HADH or HSD17B10
Reaction pageReversibleBalanced
Rhea RHEA:30799CC BY 4.0Reference data
CHEBI:131780(3S)-3-hydroxybutanoyl-CoA
Reaction pageDirection not assertedBalanced
Rhea RHEA:49592CC BY 4.0Reference data
(3S)-3-hydroxybutanoyl-CoA+water(S)-3-hydroxybutanoate+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:65208CC BY 4.0Reference data

Other names

2 names

Resolves to: (3S)-3-hydroxybutanoyl-CoA

Also called: (3S)-hydroxybutanoyl-CoA
Systematic name: 3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-4-({3-[(2-{[(3S)-3-hydroxybutanoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-2,2-dimethyl-4-oxobutyl] diphosphate}