Compound

prostaglandin J2

A prostaglandin carboxylic acid anion that is the conjugate base of prostaglandin J2, obtained by deprotonation of the carboxy group; major species at pH 7.3.

Definition from ChEBI (CHEBI:133396), read 2026-09-23. CC BY 4.0.

CHEBI:133396ChEBI

Open in the graph

Structure

2D depiction · 3D model shown

Loading the model…

A generated conformer of prostaglandin J2 — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C20H29O4
Mass: 333.448 g/mol
Charge: -1
InChIKey: UQOQENZZLBSFKO-POPPZSFYSA-M
SMILES: CCCCC[C@H](O)/C=C/[C@H]1C(=O)C=C[C@@H]1C/C=CCCCC(=O)[O-]
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

22 entities

22 entities reached.

0 reported hops22 assembled from the scaffold

Show the remaining 10

What the reference databases state

Chemical structure

prostaglandin J2-S-(R)-glutathione has the functional parent prostaglandin J2CompoundChEBI CHEBI:133771Inferred only
prostaglandin J2-S-(S)-glutathione has the functional parent prostaglandin J2CompoundChEBI CHEBI:133772Inferred only

Statements

37 statements

37 statements · 2 reference databases · Subject: prostaglandin J2 · Sources: Human-GEM, Rhea

Order

prostaglandin J2 is converted to prostaglandin D2CompoundHuman-GEM MAR01332Inferred only
prostaglandin J2 is converted to prostaglandin D2CompoundHuman-GEM MAR01333Inferred only
prostaglandin D2 is converted to prostaglandin J2CompoundHuman-GEM MAR01332Inferred only
prostaglandin D2 is converted to prostaglandin J2CompoundHuman-GEM MAR01333Inferred only
prostaglandin J2 is metabolised by GSTA1ProteinRhea RHEA:50804Inferred only
prostaglandin J2 is metabolised by GSTA1ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTA2ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTA3ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTA4ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTA5ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTK1ProteinHuman-GEM MAR03942Inferred only
prostaglandin J2 is metabolised by GSTK1ProteinHuman-GEM MAR01367Inferred only

Show the remaining 25

prostaglandin J2 is metabolised by GSTM1ProteinRhea RHEA:50808Inferred only
prostaglandin J2 is metabolised by GSTM1ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTM1ProteinRhea RHEA:50804Inferred only
prostaglandin J2 is metabolised by GSTM2ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTM3ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTM4ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTM5ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTO1ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTO2ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTP1ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTP1ProteinRhea RHEA:50808Inferred only
prostaglandin J2 is metabolised by GSTP1ProteinRhea RHEA:50804Inferred only
prostaglandin J2 is metabolised by GSTT2BProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is metabolised by GSTZ1ProteinHuman-GEM MAR03942Inferred only
prostaglandin J2 is metabolised by GSTZ1ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is a substrate of AKR1C3ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is a substrate of HPGDSProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is a substrate of MGST1ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is a substrate of MGST1ProteinHuman-GEM MAR03943Inferred only
prostaglandin J2 is a substrate of MGST1ProteinHuman-GEM MAR03942Inferred only
prostaglandin J2 is a substrate of MGST2ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is a substrate of MGST2ProteinHuman-GEM MAR03943Inferred only
prostaglandin J2 is a substrate of MGST3ProteinHuman-GEM MAR03943Inferred only
prostaglandin J2 is a substrate of MGST3ProteinHuman-GEM MAR01367Inferred only
prostaglandin J2 is a substrate of PTGESProteinHuman-GEM MAR01367Inferred only

Reactions

17 reactions

11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate+15-oxoprostaglandin E1+MAM00014x+(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate+MAM00254c+MAM00254m+MAM00254x+20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00274c+MAM00274r+MAM00276c+MAM00277c+MAM00278c+MAM00280c+MAM00282c+11beta-hydroxyandrost-4-ene-3,17-dione+11beta-hydroxyandrost-4-ene-3,17-dione+11beta-hydroxyandrost-4-ene-3,17-dione+MAM00293c+MAM00297c+MAM00298c+MAM00304c+MAM00306c+MAM00308c+MAM00318c+MAM00318r+MAM00319c+MAM00320c+MAM00321c+MAM00322c+MAM00323c+MAM00323r+MAM00324r+MAM00327c+MAM00327r+MAM00328c+MAM00328r+MAM00333r+12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate+(13S)-hydroxy-(9Z,11E)-octadecadienoate+MAM00338c+MAM00340c+MAM00352r+13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00364c+14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate+MAM00378c+MAM00382c+15-deoxy-Delta(12,14)-prostaglandin J2+MAM00384c+MAM00386c+MAM00386r+MAM00386x+MAM00387c+MAM00387r+MAM00387x+MAM00388c+MAM00388r+MAM00388x+MAM00389c+MAM00389r+MAM00389x+15-oxoprostaglandin F2alpha+MAM00395c+16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00398x+17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00424m+MAM00425x+MAM00426c+18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00430c+MAM00590c+MAM00595c+MAM00595r+MAM00598c+MAM00598r+MAM00602c+MAM00687m+MAM00687x+MAM01038n+MAM01039x+MAM01041n+MAM01046c+MAM01047c+MAM01049c+MAM01050c+MAM01051c+5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+MAM01055c+MAM01120c+MAM01120r+MAM01122c+MAM01122r+MAM01150c+MAM01150m+MAM01150x+MAM01153c+MAM01153m+MAM01153r+MAM01153x+MAM01167c+MAM01168r+MAM01171c+MAM01171m+MAM01171x+MAM01172c+MAM01172m+MAM01172x+7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM01202c+MAM01208c+8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate+MAM01210c+MAM01213c+MAM01239c+(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate+(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate+MAM02368c+MAM02395n+MAM02395r+MAM02395x+MAM02396r+MAM02396x+malonaldehyde+MAM02538c+MAM02538n+MAM02649m+MAM02649x+prostaglandin E2+prostaglandin E3+prostaglandin H1+prostaglandin J2+MAM02797c+MAM02798c+MAM02799c+MAM02851c+MAM02852c+MAM02862c+MAM02863c+MAM02864c+MAM03055c+MAM03055r+MAM03055x+MAM03056cMAM10003e
Reaction pageLeft to rightBalance undeterminableGO:0005829, GO:0005777, GO:0005759, GO:0005783, GO:0005634, GO:0005615
Human-GEM MAR00036CC BY 4.0Reference data
water+prostaglandin J2prostaglandin D2
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR01332CC BY 4.0Reference data
water+prostaglandin J2prostaglandin D2
Reaction pageReversibleBalancedGO:0005783
Human-GEM MAR01333CC BY 4.0Reference data
CHEBI:16856+prostaglandin J2MAM02864c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 10 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.188, 2.5.1.18GO:0005829
Human-GEM MAR01367CC BY 4.0Reference data
MAM01662cprostaglandin J2
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR01373CC BY 4.0Reference data
MAM00385c+waterprostaglandin J2
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR01375CC BY 4.0Reference data
prostaglandin J2MAM01662m
Reaction pageReversibleBalancedEC 1.5.1.38, 1.5.1.39, 1.5.1.41GO:0005759
Human-GEM MAR03834CC BY 4.0Reference data
prostaglandin J2MAM01662r
Reaction pageReversibleBalancedGO:0005783
Human-GEM MAR03836CC BY 4.0Reference data
CHEBI:16856+prostaglandin J2MAM02864m
Catalysed by MGST1 or GSTZ1 or GSTK1
Reaction pageReversibleBalancedEC 2.5.1.18GO:0005759
Human-GEM MAR03942CC BY 4.0Reference data
CHEBI:16856+prostaglandin J2MAM02864r
Catalysed by MGST1 or MGST2 or MGST3
Reaction pageReversibleBalancedEC 2.5.1.18GO:0005783
Human-GEM MAR03943CC BY 4.0Reference data
(S)-lactic acid+prostaglandin J2(S)-lactic acid+prostaglandin J2
Reaction pageReversibleBalancedGO:0005615, GO:0005829
Human-GEM MAR10134CC BY 4.0Reference data
prostaglandin J2prostaglandin J2
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR10135CC BY 4.0Reference data

Show the remaining 5

Other names

2 names

Resolves to: prostaglandin J2

Also called: PGJ2
Systematic name: (5Z,13E,15S)-15-hydroxy-11-oxoprosta-5,9,13-trien-1-oate