(3S)-3-hydroxybutanoyl-CoA

1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase

Catalysed by ACAA1, HSD17B4, EHHADHperoxisomeOne of 2 routes

1. (3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)

Catalysed by HADH, HSD17B10

1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

Catalysed by ACAA1, HSD17B4, EHHADH, HMGCS1peroxisome, cytosolOne of 3 routes

1. (3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)
2. acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)

Catalysed by HADH, HSD17B10, ACOT8

1. (3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)
2. acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)
3. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate

Catalysed by HADH, HSD17B10, ACOT8, ADHFE1

1. (S)-3-Hydroxybutanoyl-CoA:NAD+ oxidoreductase
2. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
3. Carnitine O-Palmitoyltransferase

Catalysed by and 3 more