(S)-3-hydroxybutanoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

144 compounds within 3 steps: 2 in 1, 16 in 2, 126 in 3

One step

acetoacetateReach from here →
1. AKG[m] + (S)-3-hydroxybutanoate[m] = acetoacetate[m] + (R)-2-hydroxyglutarate[m]
Catalysed by ADHFE1mitochondrial matrixOne of 2 routes
(R)-2-hydroxyglutarateReach from here →
1. AKG[m] + (S)-3-hydroxybutanoate[m] = acetoacetate[m] + (R)-2-hydroxyglutarate[m]
Catalysed by ADHFE1mitochondrial matrixOne of 2 routes

Two steps

2-hydroxybutyric acidReach from here →
1. AKG[m] + (S)-3-hydroxybutanoate[m] = acetoacetate[m] + (R)-2-hydroxyglutarate[m]
2. transport of 2-hydroxybutyrate and acetoacetate (cytosol to extracellular)
Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A7 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes
CHEBI:15345Reach from here →
1. AKG[m] + (S)-3-hydroxybutanoate[m] = acetoacetate[m] + (R)-2-hydroxyglutarate[m]
2. Acetoacetate:CoA ligase (AMP-forming)
Catalysed by ADHFE1, AACSmitochondrial matrix, cytosol

Three steps

One of 3 routes

acetoneReach from here →

Catalysed by ADHFE1mitochondrial matrix

pyruvateReach from here →

Catalysed by ADHFE1mitochondrial matrix, cytosolOne of 4 routes

all-trans-retinoic acidReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5mitochondrial matrix, extracellular space, cytosolOne of 2 routes

4-hydroxybutanoateReach from here →

Catalysed by ADHFE1mitochondrial matrix

(R)-3-hydroxybutyric acidReach from here →

Catalysed by ADHFE1, BDH1, BDH2mitochondrial matrixOne of 4 routes

AH2Reach from here →

Catalysed by ADHFE1, D2HGDHmitochondrial matrix

4-fumarylacetoacetateReach from here →

Catalysed by ADHFE1, FAHmitochondrial matrix

acetateReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A6 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

formic acidReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5mitochondrial matrix, extracellular space, cytosolOne of 2 routes

propionic acidReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A7 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

butyric acidReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A7 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

(S)-lactic acidReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A7 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

(3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →

Catalysed by ADHFE1, HMGCL, HMGCLL1mitochondrial matrix

acetoacetyl-CoAReach from here →

Catalysed by ADHFE1, AACSmitochondrial matrixOne of 2 routes

Catalysed by ADHFE1, D2HGDH, MOCS1mitochondrial matrix

AReach from here →

Catalysed by ADHFE1, D2HGDH, AIFM1, PYROXD1mitochondrial matrixOne of 70 routes

(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

Catalysed by ADHFE1, D2HGDH, PTGS2mitochondrial matrix

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

Catalysed by ADHFE1, D2HGDH, PTGS2mitochondrial matrix

prostaglandin E3Reach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A7 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

prostaglandin H3Reach from here →

Catalysed by ADHFE1, D2HGDH, PTGS2mitochondrial matrix

prostaglandin A2Reach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A7 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

prostaglandin J2Reach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A7 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A7 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

13-hydroxy-(9Z,11E)-octadecadienoateReach from here →

Catalysed by ADHFE1, D2HGDH, PTGS2mitochondrial matrix

9-hydroxy-(10E,12Z)-octadecadienoateReach from here →

Catalysed by ADHFE1, D2HGDH, PTGS2mitochondrial matrix

all-trans-4-hydroxyretinoateReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, CYP26A1mitochondrial matrix, extracellular space, cytosolOne of 3 routes

N-acetylcadaverineReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A6 and 3 moremitochondrial matrix, extracellular space, cytosol

(13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →

Catalysed by ADHFE1, D2HGDH, PTGS1, PTGS2mitochondrial matrix

2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

Catalysed by ADHFE1, D2HGDH, PTGS2mitochondrial matrix

2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

Catalysed by ADHFE1, D2HGDH, PTGS2mitochondrial matrix

2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →

Catalysed by ADHFE1, D2HGDH, PTGS2mitochondrial matrix

2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →

Catalysed by ADHFE1, D2HGDH, PTGS2mitochondrial matrix

2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →

Catalysed by ADHFE1, D2HGDH, PTGS2mitochondrial matrix

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, UGT1A1 and 2 moremitochondrial matrix, extracellular space, cytosol, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, CYP1A1 and 24 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

a phenyl acetateReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A6 and 5 moremitochondrial matrix, extracellular space, cytosol

acetylpyruvateReach from here →

Catalysed by ADHFE1, FAHD1mitochondrial matrix, cytosolOne of 2 routes

CHEBI:15467Reach from here →

Catalysed by ADHFE1, AACS, HMGCS1mitochondrial matrix, cytosolOne of 3 routes

propionyl-CoAReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, SLC16A7 and 5 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

(S)-malateReach from here →

Catalysed by ADHFE1, ME2mitochondrial matrix, cytosolOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by ADHFE1, SLC16A4, SLC16A5, MTHFD1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by ADHFE1, AGXT2mitochondrial matrix, cytosol

cob(II)alaminReach from here →

Catalysed by ADHFE1, D2HGDH, MTRRmitochondrial matrix

iodideReach from here →

Catalysed by ADHFE1, D2HGDH, DIO1, DIO3mitochondrial matrixOne of 22 routes

oxaloacetateReach from here →

Catalysed by ADHFE1, PCmitochondrial matrix, cytosolOne of 3 routes