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Proteins/UNIPROT:P54868
Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate..
Function from UniProtKB (P54868), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
57 statements
57 statements · 7 reference databases · Subject: HMGCS2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
CHEBI:15345+CHEBI:15351+waterCHEBI:1146900+proton+CHEBI:15467
Catalysed by HMGCS2
Reaction pageLeft to rightBalancedEC 2.3.3.10mitochondrial matrix
Human-GEM MAR01573CC BY 4.0Reference data
acetoacetyl-CoA+acetyl-CoA+water(3S)-3-hydroxy-3-methylglutaryl-CoA+coenzyme A(4-)
2 names
Resolves to: HMGCS2
Reaction pageLeft to rightBalanced
Rhea RHEA:10188CC BY 4.0Reference data