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Proteins/UNIPROT:Q9BUT1
NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase..
Function from UniProtKB (Q9BUT1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
74 statements
74 statements · 6 reference databases · Subject: BDH2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
8 reactions
7 names
Resolves to: BDH2
Human-GEM MAR01098CC BY 4.0Reference data
MAM00747r+proton+NADPH(4-)MAM01087r+NADP(3-)
Catalysed by HSD17B14 or HSD3B7 or DHRS2 or HTATIP2 or RDH10 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 and 12 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-endoplasmic reticulum
Human-GEM MAR01813CC BY 4.0Reference data
(R)-3-hydroxybutyric acid+NAD(+)acetoacetate+proton+NADH(2-)
Reaction pageReversibleBalancedEC 1.1.1.30mitochondrial matrix
Human-GEM MAR04461CC BY 4.0Reference data
MAM01029c+proton+NADPH(4-)MAM01229c+NADP(3-)
Catalysed by HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or RDH13 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or HSD11B2 or SDR42E2 and 10 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR06670CC BY 4.0Reference data
4-methyl-2-oxopentanoate+proton+NADH(2-)2-hydroxy-4-methylvaleric acid+NAD(+)
Catalysed by DHRS2 or HTATIP2 or MDH1B or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or SDR42E2 or SDR42E1 or WWOX and 6 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR06925CC BY 4.0Reference data
MAM00799m+NADP(3-)proton+NADPH(4-)+MAM03168m
Catalysed by DHRS2 or HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR42E2 or SDR42E1 or WWOX and 7 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-mitochondrial matrix
Human-GEM MAR09804CC BY 4.0Reference data
CHEBI:63727+NAD(1-)CHEBI:84813+NADH(2-)+hydron
Catalysed by BDH2
Reaction pageRight to leftBalanced
Rhea RHEA:13601CC BY 4.0Reference data
(R)-3-hydroxybutyric acid+NAD(1-)acetoacetate+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:20521CC BY 4.0Reference data