glyoxylate

Two steps

• an N-(fatty acyl)-glycineReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by AADAT, GLYATL2

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by AADAT, GLYATL2

• acetylpyruvateReach from here →
  1. glyoxylate + L-alanine = glycine + pyruvate
  2. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by AGXT, AGXT2, FAHD1

• all-trans-retinoic acidReach from here →
  1. glyoxylate + L-alanine = glycine + pyruvate
  2. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosolOne of 2 routes

• propionyl-CoAReach from here →
  1. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  2. 2-oxobutyrate oxidation

  Catalysed by AGXT2cytosol

• CHEBI:15570Reach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by AADAT, SLC3A2, SLC7A10extracellular space, cytosolOne of 2 routes

• L-leucineReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5extracellular space, cytosolOne of 7 routes

• CHEBI:15611Reach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by AADAT, GNMTcytosol

• CHEBI:15699Reach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5extracellular space, cytosolOne of 4 routes

• formateReach from here →
  1. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)
  2. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by HAO1, SLC26A6inner side of the membrane, outer side of the membraneOne of 2 routes

• malonateReach from here →
  1. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  2. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

  Catalysed by CLYBL, SLC25A10inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:15971Reach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A6extracellular space, cytosolOne of 2 routes

• homogentisateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by AADAT, HPDcytosolOne of 2 routes

• sulfateReach from here →
  1. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by HAO1, SLC25A14, SLC26A2, SLC25A30 and 2 moreinner side of the membrane, outer side of the membraneOne of 6 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. glyoxylate + L-alanine = glycine + pyruvate
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by AGXT, AGXT2mitochondrial matrix

• L-citrullineReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A9, SLC3A1, SLC7A6extracellular space, cytosol

• L-valineReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of glycine and valine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5extracellular space, cytosolOne of 4 routes

• oxaloacetateReach from here →
  1. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  2. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by CLYBLmitochondrial matrix, cytosolOne of 9 routes

• L-arginineReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A6extracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by AADAT, SLC3A2, SLC7A10extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. PROTEIN_BS

  Catalysed by AADATcytosol

• (S)-lactateReach from here →
  1. glyoxylate + L-alanine = glycine + pyruvate
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by AGXT, AGXT2, LDHA, LDHB and 3 more

• 2-oxoglutaramateReach from here →
  1. glyoxylate + L-alanine = glycine + pyruvate
  2. L-Glutamine:pyruvate aminotransferase

  Catalysed by AGXT, AGXT2, KYAT1cytosolOne of 3 routes

• enol-phenylpyruvateReach from here →
  1. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  2. 3-phenylpyruvate = enol-phenylpyruvate

  Catalysed by AADAT, MIF

• 3-fumarylpyruvateReach from here →
  1. glyoxylate + L-alanine = glycine + pyruvate
  2. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by AGXT, AGXT2, FAHD1

• CHEBI:16856Reach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by AADAT, GSScytosol

• CHEBI:16857Reach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by AADAT, SLC3A2, SLC7A5, SLC7A10extracellular space, cytosolOne of 4 routes

• glyoxylic acidReach from here →
  1. glycolate + NADP(+) = glyoxylate + NADPH + H(+)
  2. glycolate:NADP+ oxidoreductase

  Catalysed by GRHPRcytosolOne of 4 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. glyoxylate + L-alanine = glycine + pyruvate
  2. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. glyoxylate + L-alanine = glycine + pyruvate
  2. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by AGXT, AGXT2

• L-isoleucineReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5extracellular space, cytosolOne of 4 routes

• CHEBI:17203Reach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of glycine and proline (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5, SLC7A6extracellular space, cytosolOne of 2 routes

• (S)-4-hydroxymandelateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. 3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2

  Catalysed by AADAT, HPDL

• aceneuramateReach from here →
  1. glyoxylate + L-alanine = glycine + pyruvate
  2. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by AGXT, AGXT2, NPL

• 5'-deoxyadenosineReach from here →
  1. glyoxylate + L-alanine = glycine + pyruvate
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by AGXT, AGXT2, TYW1B, TYW1

• sulfiteReach from here →
  1. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  2. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by CLYBL, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:17380Reach from here →
  1. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
  2. Kynurenine-Oxoglutarate Transaminase

  Catalysed by KYAT3, AADATmitochondrial matrixOne of 2 routes

• enol-oxaloacetateReach from here →
  1. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by CLYBL, SDHB, SDHA

• 5-aminolevulinic acidReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by AADAT, ALAS1, ALAS2, CPNE7mitochondrial matrix

• L-cysteineReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by AADAT, SLC3A2, SLC7A5, SLC7A8extracellular space, cytosolOne of 4 routes

• CHEBI:17895Reach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5extracellular space, cytosolOne of 4 routes

• fumaric acidReach from here →
  1. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  2. (S)-malate hydro-lyase (fumarate-forming)

  Catalysed by CLYBL, FHcytosolOne of 5 routes

• CHEBI:18019Reach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A6extracellular space, cytosolOne of 2 routes

• L-glutamineReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5extracellular space, cytosolOne of 4 routes

• dTDPReach from here →
  1. glyoxylate + L-alanine = glycine + pyruvate
  2. pyruvate kinase (dTDP)

  Catalysed by AGXT, AGXT2, PKM, PKLRcytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by AADAT, GARTcytosol

• ophthalmateReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by AADAT, GSS

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  2. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by AGXT2, BCKDHA, BCKDHBmitochondrial matrix

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AADAT, AGXT2One of 3 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by AADAT, SHMT1cytosolOne of 2 routes