CHEBI:240943

Three steps

• palmitoyl-CoAReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by GLYAT, GLYATL2, GLYATL1, CPT1A and 2 moremitochondrial matrix, cytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Phenylacetate:CoA ligase

  Catalysed by GLYAT, GLYATL2, GLYATL1mitochondrial matrix, cytosolOne of 4 routes

• propionyl-CoAReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, ACSS3 and 2 moremitochondrial matrix, cytosolOne of 45 routes

• (S)-malateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine:oxygen oxidoreductase (deaminating)
  3. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]

  Catalysed by GLYAT, GLYATL2, GLYATL1, DAO and 1 moremitochondrial matrix, peroxisomeOne of 6 routes

• (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by GLYAT, GLYATL2, GLYATL1, SHMT1 and 1 moremitochondrial matrixOne of 2 routes

• 10-formyltetrahydrofolic acidReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SHMT1 and 1 moremitochondrial matrix, cytosolOne of 5 routes

• 5-methyltetrahydrofolic acidReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. histamine N-methyltransferase (SAM)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SHMT1 and 1 moremitochondrial matrix, cytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• CHEBI:15650Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by GLYAT, GLYATL2, GLYATL1, ZDHHC11B and 31 moremitochondrial matrix, cytosolOne of 6 routes

• betaine aldehydeReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and choline (cytosol to extracellular)
  3. choline dehydrogenase (choline)

  Catalysed by SLC6A5, SLC5A7, CHDHextracellular space, cytosolOne of 3 routes

• trimethylenediamineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A6 and 1 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:15727Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by GLYAT, GLYATL2, GLYATL1, NAA10mitochondrial matrix, cytosolOne of 3 routes

• CHEBI:15746Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SAT1 and 1 moremitochondrial matrix, cytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A5, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• CHEBI:15765Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

• malonateReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by SLC6A5, SLC26A6, SLC25A14, SLC25A30 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• bromideReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 17 moremitochondrial matrix, cytosolOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 2 moremitochondrial matrix, extracellular space, cytosol

• thioredoxin dithiolReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine:tRNA(Gly) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by GLYAT, GLYATL2, GLYATL1, GARS1mitochondrial matrix, cytosolOne of 2 routes

• a halide anionReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 23 moremitochondrial matrix

• ureaReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A6 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• succinic semialdehydeReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. 4-aminobutanoate:2-oxoglutarate aminotransferase

  Catalysed by SLC6A5, SLC6A12, ABATextracellular space, cytosol, mitochondrial matrix

• L-cystineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 8 routes

• 11-cis-retinolReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, DGAT1 and 4 moremitochondrial matrix, cytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 3 moremitochondrial matrix, extracellular space, cytosol

• lithocholic acidReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• (R)-carnitineReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of betaine and chloride (cytosol to extracellular)
  3. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

  Catalysed by SLC6A5, SLC6A12, SLC22A5extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• oxaloacetateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. ATP citrate lyase (citrate)

  Catalysed by GLYAT, GLYATL2, GLYATL1, ACLYmitochondrial matrix, cytosol

• nitric oxideReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A6 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. L-Arginine:glycine amidinotransferase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by GLYAT, GLYATL2, GLYATL1, GATM and 1 moremitochondrial matrix, cytosol

• 2-phenylacetamideReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosol

• D-alanyl-D-alanineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of D-alanine and glycine (cytosol to extracellular)
  3. Formation of Alanylalanine

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 1 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 3 moremitochondrial matrix, extracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosol

• quinolinic acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Quinolinic Acid

  Catalysed by SLC6A5, SLC26A6, SLC22A6extracellular space, cytosolOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

• tryptamineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• formaldehydeReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase
  3. sarcosine:oxygen oxidoreductase (demethylating)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GNMT and 2 moremitochondrial matrix, cytosol, peroxisomeOne of 2 routes

• creatineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. L-Arginine:glycine amidinotransferase
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, GATM and 1 moremitochondrial matrix, cytosolOne of 2 routes

• bilirubin IXalphaReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of (R)-3-hydroxybutanoate and formate (cytosol to extracellular)

  Catalysed by SLC6A5, SLC26A4, SLC16A4, SLC16A5 and 2 moreextracellular space, cytosolOne of 2 routes

• taurolithocholateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• CHEBI:17208Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSSmitochondrial matrix, cytosol

• homocysteineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Formation of Homocystine

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSSmitochondrial matrix, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. L-Arginine:glycine amidinotransferase
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, GATM and 1 moremitochondrial matrix, cytosol

• anilineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, NAT2 and 1 moremitochondrial matrix, cytosol