3,3'-diiodo-L-thyronine

Three steps

• 13-cis-retinolReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. retinol binding protein (retinol)

  Catalysed by DIO3, RETSAT, RBP1, RBP2cytosolOne of 2 routes

• L-ornithineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A6extracellular space, cytosolOne of 2 routes

• gamma-Glu-AlaReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 7 morecytosol, extracellular space

• taurineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by DIO3, SLC26A4, SLC6A6extracellular space, cytosolOne of 2 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by DIO3, AIFM1, PYROXD1, RETSATOne of 2 routes

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by DIO1, DIO3, DIO2cytosolOne of 2 routes

• glycineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 7 routes

• prostaglandin E1Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• prostaglandin I2Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• prostaglandin H2Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 6 routes

• prostaglandin D2Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 10 morecytosol, extracellular spaceOne of 2 routes

• sarcosineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by DIO3, KDM1A, KDM1B, PIPOX

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)

  Catalysed by DIO3, MTO1, DHFR, DHFR2

• leukotriene A4Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 4 routes

• (R)-S-lactoylglutathioneReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 3 morecytosol, extracellular spaceOne of 2 routes

• 3,5-diiodo-L-tyrosineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. iodide:hydrogen-peroxide oxidoreductase
  3. thyroid peroxidase (3-iodo-L-tyrosine)

  Catalysed by DIO3, TPOcytosolOne of 2 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by DIO3, MOCOS, GOT2, GOT1cytosolOne of 3 routes

• S-formylglutathioneReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 7 morecytosol, extracellular spaceOne of 2 routes

• guanidinoacetateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by DIO3, SLC26A4extracellular space, cytosol

• L-methionineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by DIO3, AIFM1, PYROXD1, CDK5RAP1One of 12 routes

• N-sulfo-D-glucosamineReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by STS, SGSHGolgi apparatus

• dehydroepiandrosterone 3-sulfateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by STSGolgi apparatusOne of 3 routes

• L-tryptophanReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and tryptophan (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes

• beta-alanineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by DIO3, SLC26A4, SLC6A6, SLC6A14extracellular space, cytosolOne of 2 routes

• L-alanineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by DIO3, AIFM1, PYROXD1, SCLYOne of 19 routes

• leukotriene C4Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. leukotriene C4 synthase (GSH)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 6 routes

• L-asparagineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes

• L-phenylalanineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 8 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by DIO3, MOCOS, GCLC, GCLMcytosolOne of 2 routes

• adenosine 5'-phosphosulfateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. ATP:sulfate adenylyltransferase

  Catalysed by STS, PAPSS1, PAPSS2Golgi apparatus, cytosolOne of 4 routes

• glutathione disulfideReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 10 morecytosol, extracellular spaceOne of 13 routes

• taurolithocholate 3-sulfateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• histamineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• S-sulfanyl-L-cysteineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by DIO3, MOCOS, CARS2

• phosphoenolpyruvateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by DIO3, D2HGDH, PCK1, PCK2

• S-sulfanylglutathioneReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 2 morecytosol, extracellular space, mitochondrial matrix

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by DIO3, MOCOS, PPCScytosolOne of 4 routes

• 4-aminobutanoateReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by DIO3, SLC26A4, SLC6A12extracellular space, cytosolOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. iodide:hydrogen-peroxide oxidoreductase
  3. thyroid peroxidase (iodine)

  Catalysed by DIO3, TPOcytosolOne of 2 routes

• dopamineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• glycolithocholate 3-sulfateReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• estrone 3-sulfateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by STSGolgi apparatusOne of 3 routes

• prostaglandin E2Reach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 4 routes

• 3-sulfino-L-alanineReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by DIO3, MOCOS, CDO1cytosolOne of 2 routes

• L-cysteinylglycineReach from here →
  1. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by DIO1, DIO3, DIO2, SLCO1A2 and 7 morecytosol, extracellular spaceOne of 4 routes

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by STS, SLC4A1Golgi apparatus, extracellular space, cytosolOne of 2 routes

• an all-trans-retinyl esterReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. Lecithin Retinol Acyltransferase

  Catalysed by DIO3, RETSAT, LRATcytosolOne of 4 routes

• a 2,3-saturated acyl-CoAReach from here →
  1. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by DIO3, AIFM1, PYROXD1, ACAD10One of 2 routes