glyoxylic acid

Two steps

• a quinolReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by CLYBL, SDHB, SDHAmitochondrial matrix

• phenylacetylglycineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by AGXT, AGXT2, GLYATmitochondrial matrix, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by CLYBL, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• CHEBI:28666Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. LTD4 hydrolysis

  Catalysed by AGXT, AGXT2mitochondrial matrix, cytosol

• CHEBI:28701Reach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by CLYBL, ACAA1, SCP2, MYO5Bmitochondrial matrix, peroxisomeOne of 7 routes

• Gly-tRNA(Gly)Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by AGXT, AGXT2, GARS1mitochondrial matrix, cytosol

• chlorine(.)Reach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC6A9, SLC6A14mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• glycocholateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by AGXT, AGXT2, BAATmitochondrial matrix, peroxisomeOne of 3 routes

• acetateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC16A4, SLC16A5 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• formic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC16A4, SLC16A5 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• propionic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC16A4, SLC16A5 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• citric acidReach from here →
  1. Glyoxylate:oxygen oxidoreductase
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by HAO1, SLC25A1peroxisome, mitochondrial matrix, cytosolOne of 8 routes

• butyric acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by AGXT, AGXT2, SLC16A4, SLC16A5 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. L-Serine:pyruvate aminotransferase

  Catalysed by AGXT, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• isocitric acidReach from here →
  1. Glyoxylate:oxygen oxidoreductase
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by HAO1, SLC25A1peroxisome, mitochondrial matrix, cytosolOne of 6 routes

• cis-aconitic acidReach from here →
  1. Glyoxylate:oxygen oxidoreductase
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by HAO1, SLC25A1peroxisome, mitochondrial matrix, cytosolOne of 6 routes

• 3-oxopropanoateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by AGXT, AGXT2mitochondrial matrix

• thiosulfateReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. transport of malate and thiosulfate (cytosol to mitochondria)

  Catalysed by CLYBL, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• D-serineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. D-serine = pyruvate + NH4(+)

  Catalysed by AGXT, AGXT2, SRRmitochondrial matrix

• 5-aminolevulinateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by AGXT, AGXT2, ALAS1, ALAS2mitochondrial matrix

• glycochenodeoxycholateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by AGXT, AGXT2, BAATmitochondrial matrix

• glycochenodeoxycholic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by AGXT, AGXT2, BAATmitochondrial matrix, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by AGXT, AGXT2, AADATmitochondrial matrixOne of 14 routes

• glycolithocholic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by AGXT, AGXT2, BAATmitochondrial matrix, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by AGXT, AGXT2, GCATmitochondrial matrix

• (R)-lactic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by AGXT, AGXT2, LDHDmitochondrial matrix, cytosol

• (S)-lactic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by AGXT, AGXT2, LDHB, LDHAL6Bmitochondrial matrixOne of 5 routes

• 2-iminopropanoateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by AGXT, AGXT2, RIDAmitochondrial matrix

• phosphoenolpyruvic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. pyruvate kinase (dTDP)

  Catalysed by AGXT, AGXT2, PKM, PKLRmitochondrial matrix, cytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by AGXT, AGXT2, NPLmitochondrial matrix, cytosol

• L-ornithineReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. L-Arginine:glycine amidinotransferase

  Catalysed by AGXT, AGXT2, GATMmitochondrial matrix, cytosolOne of 5 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by AGXT, AGXT2, GLDC, GCSHmitochondrial matrix

• taurineReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by CLYBL, BAATmitochondrial matrix, cytosolOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. L-Alanine:glyoxylate aminotransferase
  2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by AGXT, AGXT2, FAHD1mitochondrial matrix

• (S)-malyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by CLYBL, SUCLG1, SUCLA2mitochondrial matrix

• (R)-methylmalonyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by CLYBL, ALDH6A1mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by CLYBLmitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by CLYBL, ACP2mitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by CLYBLmitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by CLYBL, ACAA1, MYO5Bmitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by CLYBL, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Production of Glutaryl Carnitine

  Catalysed by CLYBL, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by CLYBL, SUCLG1, SUCLG2, SUCLA2mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by CLYBL, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by CLYBL, CROTmitochondrial matrixOne of 20 routes