3beta-hydroxy-5alpha-androstan-17-one

1. 3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)

Catalysed by HSD3B1

1. 3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)
2. Androsterone:NAD+ oxidoreductase

Catalysed by HSD3B1, AKR1C4, AKR1C3, AKR1C2 and 1 morecytosolOne of 6 routes

1. 3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)
2. 17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)

Catalysed by HSD3B1, AKR1B15, HSD17B3, AKR1C1

1. 3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)
2. 5alpha-androstane-3,17-dione:NADP+ delta4-oxidoreductase

Catalysed by HSD3B1, AKR1D1cytosolOne of 3 routes

1. 3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)
2. Androsterone:NAD+ oxidoreductase
3. steroid sulfatase (androsterone sulfate)

Catalysed by HSD3B1, AKR1C4, AKR1C3, AKR1C2 and 2 morecytosolOne of 4 routes

1. 3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)
2. 17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)
3. glucuronosyltransferase (5-alpha-dihydrotestosterone)