Compound
androst-4-ene-3,11,17-trione
A 3-oxo Δ4-steroid that is androst-4-ene carrying three oxo-substituents at positions 3, 11 and 17.
Definition from ChEBI (CHEBI:2495), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C19H24O3
- Mass
- 300.398 g/mol
- Charge
- 0
- InChIKey
- RZRPTBIGEANTGU-IRIMSJTPSA-N
- SMILES
- [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])C(=O)C[C@]1(C)C(=O)CC[C@@]21[H]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- AKR1C3ProteinUNIPROT:P42330substrate ofInferred only35 paths35 endpoints
- HSD17B3ProteinUNIPROT:P37058substrate ofInferred only17 paths17 endpoints
- HSD11B1ProteinUNIPROT:P28845substrate ofInferred only15 paths15 endpoints
- AKR1D1ProteinUNIPROT:P51857substrate ofInferred only15 paths15 endpoints
- DHRS11ProteinUNIPROT:Q6UWP2substrate ofInferred only1 path1 endpoint
What the reference databases state
Statements
8 statements
8 statements · 1 reference database · Subject: androst-4-ene-3,11,17-trione · Sources: Rhea
- androst-4-ene-3,11,17-trione is converted to 11beta-hydroxyandrost-4-ene-3,17-dioneCompoundRhea RHEA:86411Inferred only
- 11beta-hydroxyandrost-4-ene-3,17-dione is converted to androst-4-ene-3,11,17-trioneCompoundRhea RHEA:69408Inferred only
- 11beta-hydroxyandrost-4-ene-3,17-dione is converted to androst-4-ene-3,11,17-trioneCompoundRhea RHEA:86411Inferred only
- androst-4-ene-3,11,17-trione is a substrate of AKR1C3ProteinRhea RHEA:53484Inferred only
- androst-4-ene-3,11,17-trione is a substrate of AKR1D1ProteinRhea RHEA:53484Inferred only
- androst-4-ene-3,11,17-trione is a substrate of DHRS11ProteinRhea RHEA:53484Inferred only
- androst-4-ene-3,11,17-trione is a substrate of HSD11B1ProteinRhea RHEA:86411Inferred only
- androst-4-ene-3,11,17-trione is a substrate of HSD17B3ProteinRhea RHEA:53484Inferred only
Reactions
3 reactions
androst-4-ene-3,11,17-trione+NADPH(4-)+hydronCHEBI:34133+NADP(3-)
Catalysed by HSD17B3 or AKR1C3 or AKR1D1 or DHRS11
Reaction pageLeft to rightBalanced
Rhea RHEA:53484CC BY 4.0Reference data
11beta-hydroxyandrost-4-ene-3,17-dione+NAD(1-)androst-4-ene-3,11,17-trione+NADH(2-)+hydron
Catalysed by HSD11B2
Reaction pageLeft to rightBalanced
Rhea RHEA:69408CC BY 4.0Reference data
11beta-hydroxyandrost-4-ene-3,17-dione+NADP(3-)androst-4-ene-3,11,17-trione+NADPH(4-)+hydron
Catalysed by HSD11B1
Reaction pageReversibleBalanced
Rhea RHEA:86411CC BY 4.0Reference data
Other names
13 names
Resolves to: androst-4-ene-3,11,17-trione
- Also called
- 11-Keto-androstenedione11-ketoandrostenedione11-OXO11-oxoandrost-4-ene-3,17-dione11-oxoandrostenedione11-Oxy-4-androstenedione4-Androsten-3,11,17-trione4-Androstenl-3,11,17-trioneAdrenosteroneAndrenosteroneNSC 12166Reichstein's substance GST 19:4;O3