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2-hydroxyestrone

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

4 compounds within 3 steps: 3 in 1, 1 in 2, 0 in 3

Does it reach a compound?

One step

2-methoxyestroneReach from here →
1. S-adenosyl-L-methionine:2-Hydroxyestrone O-methyltransferase
Catalysed by COMT, LRTOMTcytosolOne of 3 routes
2-hydroxyestrone 3-O-(beta-D-glucuronate)Reach from here →
1. 2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + UDP + H(+)
Catalysed by UGT1A9, UGT1A1, UGT1A8
2-hydroxy-3-methoxy-estroneReach from here →
1. 2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + S-adenosyl-L-homocysteine + H(+)
Catalysed by COMT

Two steps

2-methoxyestrone 3-O-(beta-D-glucuronate)Reach from here →
1. S-adenosyl-L-methionine:2-Hydroxyestrone O-methyltransferase
2. 2-methoxyestrone + UDP-alpha-D-glucuronate = 2-methoxyestrone 3-O-(beta-D-glucuronate) + UDP + H(+)
Catalysed by COMT, LRTOMT, UGT1A8cytosol