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Proteins/UNIPROT:Q9HAW9
[Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens. Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps. Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent..
[Isoform 2]: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1..
Function from UniProtKB (Q9HAW9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · metabolized by
1 compound
1 compound.
0 reported routes1 assembled route
55 statements
55 statements · 5 reference databases · Subject: UGT1A8 · Sources: gene ontology, Human-GEM, Reactome, Rhea, WikiPathways
74 reactions
bilirubin IXalpha+UDP-alpha-D-glucuronateMAM01398r+UDP
Catalysed by UGT1A8
Reaction pageReversibleBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR01820CC BY 4.0Reference data
MAM01220c+UDP-alpha-D-glucuronateMAM01240c+proton+UDP
10 names
Resolves to: UGT1A8
Reaction pageReversibleBalancedEC 2.4.1.17cytosol
Human-GEM MAR02461CC BY 4.0Reference data
MAM01220r+UDP-alpha-D-glucuronateMAM01240r+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02462CC BY 4.0Reference data
MAM00274c+proton+UDPMAM01220c+UDP-alpha-D-glucuronate
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageReversibleBalancedEC 2.4.1.17cytosol
Human-GEM MAR02463CC BY 4.0Reference data
MAM01220r+UDP-alpha-D-glucuronateMAM00274r+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02464CC BY 4.0Reference data
MAM00314c+UDP-alpha-D-glucuronateMAM00323c+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageReversibleBalancedEC 2.4.1.17cytosol
Human-GEM MAR02467CC BY 4.0Reference data
MAM00314r+UDP-alpha-D-glucuronateMAM00323r+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02468CC BY 4.0Reference data
MAM00314c+UDP-alpha-D-glucuronateMAM00327c+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageReversibleBalancedEC 2.4.1.17cytosol
Human-GEM MAR02469CC BY 4.0Reference data
MAM00314r+UDP-alpha-D-glucuronateMAM00327r+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR02470CC BY 4.0Reference data
bilirubin IXalpha+2UDP-alpha-D-glucuronateMAM01397r+2UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR04766CC BY 4.0Reference data
MAM01923c+UDP-alpha-D-glucuronateMAM01924c+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17cytosol
Human-GEM MAR06490CC BY 4.0Reference data
MAM00766c+UDP-alpha-D-glucuronateMAM01321c+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17cytosol
Human-GEM MAR06495CC BY 4.0Reference data