Loading the page.
Proteins/UNIPROT:Q6UB35
May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2..
Function from UniProtKB (Q6UB35), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 6 reference databases · Subject: MTHFD1L · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
ATP+formic acid+5,6,7,8-tetrahydrofolic acid10-formyltetrahydrofolic acid+ADP+phosphate(3-)
Catalysed by MTHFD2 or MTHFD1L or MTHFD2L
Reaction pageLeft to rightBalancedEC 3.5.4.9, 6.3.4.3mitochondrial matrix
Human-GEM MAR04340CC BY 4.0Reference data
(6R)-5,10-methenyltetrahydrofolate+NADPH(4-)(6R)-5,10-methylenetetrahydrofolic acid
2 names
Resolves to: MTHFD1L
Reaction pageReversibleBalancedEC 1.5.1.5mitochondrial matrix
Human-GEM MAR04444CC BY 4.0Reference data
10-formyltetrahydrofolic acid+proton(6R)-5,10-methenyltetrahydrofolate+water
Catalysed by MTHFD2 or MTHFD1L or MTHFD2L
Reaction pageReversibleBalancedEC 3.5.4.9mitochondrial matrix
Human-GEM MAR04505CC BY 4.0Reference data
(6S)-5,6,7,8-tetrahydrofolate+formate+ATP(4-)(6R)-10-formyltetrahydrofolate+ADP(3-)+hydrogenphosphate
Catalysed by MTHFD1 or MTHFD1L
Reaction pageLeft to rightBalanced
Rhea RHEA:20221CC BY 4.0Reference data