5beta-dihydrotestosterone

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)

Catalysed by AKR1D1

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. 17beta-hydroxysteroid UDP-glucuronosyltransferase

Catalysed by AKR1D1, UGT2B17, UGT2B7, UGT1A1 and 3 moreendoplasmic reticulumOne of 2 routes

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. testosterone + reduced [NADPH--hemoprotein reductase] + O2 = 1beta-hydroxytestosterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AKR1D1, CYP3A4

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. testosterone + reduced [NADPH--hemoprotein reductase] + O2 = 2beta-hydroxytestosterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AKR1D1, CYP3A4

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. 17beta-hydroxy-androst-5-en-3-one = testosterone

Catalysed by AKR1D1, HSD3B1

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. testosterone + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 17beta-estradiol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Catalysed by AKR1D1, CYP19A1

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. dihydrotestosterone:NADP+ delta4-oxidoreductase

Catalysed by AKR1D1, SRD5A1, SRD5A2, SRD5A3cytosolOne of 3 routes

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+)

Catalysed by AKR1D1, HSD17B6, AKR1C4, HSD17B2 and 3 more

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. cytochrome P450 (testosterone)

Catalysed by AKR1D1, CYP19A1endoplasmic reticulumOne of 2 routes

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. sulfotransferase (PAPS)

Catalysed by AKR1D1, SULT2A1cytosol

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. cytochrome P450 (testosterone)

Catalysed by AKR1D1, CYP19A1endoplasmic reticulum

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. testosterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha,17beta-dihydroxyandrost-4-en-3-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AKR1D1, CYP2B6

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. cytochrome P450 (testosterone)

Catalysed by AKR1D1, CYP3A7endoplasmic reticulumOne of 2 routes

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. testosterone + reduced [NADPH--hemoprotein reductase] + O2 = 11beta,17beta-dihydroxyandrost-4-ene-3-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AKR1D1, CYP3A4One of 2 routes

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. testosterone + reduced [NADPH--hemoprotein reductase] + O2 = 16beta,17beta-dihydroxyandrost-4-en-3-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AKR1D1, CYP2B6, CYP46A1

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. testosterone + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxytestosterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by AKR1D1, CYP46A1

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. cytochrome P450 (testosterone)
3. transport of 2-hydroxybutyrate and formate (cytosol to extracellular)

Catalysed by AKR1D1, CYP19A1, SLC16A4, SLC16A5 and 2 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

1. 5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)
2. cytochrome P450 (testosterone)
3. 17beta-estradiol + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)