19-hydroxyandrost-4-ene-3,17-dione

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

30 compounds within 3 steps: 1 in 1, 3 in 2, 26 in 3

One step

19-oxo-androst-4-ene-3,17-dioneReach from here →
1. cytochrome P450 (19-hydroxyandrostenedione)
Catalysed by CYP19A1cytosolOne of 2 routes

Two steps

formateReach from here →
1. cytochrome P450 (19-hydroxyandrostenedione)
2. 19-oxo-androst-4-ene-3,17-dione + reduced [NADPH--hemoprotein reductase] + O2 = estrone + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)
Catalysed by CYP19A1cytosol
estroneReach from here →
1. cytochrome P450 (19-hydroxyandrostenedione)
2. cytochrome P450 (19-oxoandrostenedione)
Catalysed by CYP19A1cytosolOne of 2 routes
formic acidReach from here →
1. cytochrome P450 (19-hydroxyandrostenedione)
2. cytochrome P450 (19-oxoandrostenedione)
Catalysed by CYP19A1cytosol

Three steps

2-hydroxybutyric acidReach from here →
Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes
2-hydroxyestroneReach from here →

Catalysed by CYP19A1, CYP3A4

cytosol

One of 4 routes

estrone 3-O-(beta-D-glucuronate)Reach from here →

Catalysed by CYP19A1, UGT1A1, UGT1A10, UGT1A8cytosol, endoplasmic reticulumOne of 2 routes

acetoacetateReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

pyruvateReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

all-trans-retinoic acidReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by CYP19A1, MTHFD1cytosolOne of 2 routes

17beta-estradiolReach from here →

Catalysed by CYP19A1, HSD17B6, HSD17B1, HSD17B2 and 4 morecytosolOne of 5 routes

formaldehydeReach from here →

Catalysed by CYP19A1, ALDH9A1cytosol

(R)-3-hydroxybutyric acidReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A7 and 1 morecytosol, extracellular spaceOne of 2 routes

17alpha-estradiolReach from here →

Catalysed by CYP19A1, DHRS1cytosol

(6R)-10-formyltetrahydrofolateReach from here →

Catalysed by CYP19A1, MTHFD1, MTHFD1Lcytosol

chlorine(.)Reach from here →

Catalysed by CYP19A1, SLC26A4cytosol, extracellular spaceOne of 2 routes

acetateReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A1cytosol, extracellular spaceOne of 2 routes

oxalateReach from here →

Catalysed by CYP19A1, SLC26A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

propionic acidReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A1cytosol, extracellular spaceOne of 2 routes

butyric acidReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

(S)-lactic acidReach from here →

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →

Catalysed by CYP19A1, ADI1cytosolOne of 2 routes

S-formylglutathioneReach from here →

Catalysed by CYP19A1, ESDcytosol

N-formyl-L-kynurenineReach from here →

Catalysed by CYP19A1, AFMIDcytosol

estrone 3-sulfateReach from here →

Catalysed by CYP19A1, SULT1A3, SULT1E1, SULT1A1cytosolOne of 3 routes

16alpha-hydroxyestroneReach from here →

Catalysed by CYP19A1, CYP1A1, CYP1A2, CYP2E1 and 20 morecytosolOne of 3 routes

4-hydroxyestroneReach from here →

Catalysed by CYP19A1, CYP1A1, CYP1A2, CYP3A4 and 3 morecytosol

6alpha-hydroxyestroneReach from here →

Catalysed by CYP19A1, CYP1A1cytosol

15alpha-hydroxyestroneReach from here →

Catalysed by CYP19A1, CYP1A1cytosol