L-homoarginine

Three steps

• hydrogen sulfideReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC25A2, SLC7A6, CTHinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-aspartateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by SLC25A2, SLC7A6, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 22 routes

• acetateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. N2-Acetyl-L-ornithine amidohydrolase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SLC25A2, ACY1inner side of the membrane, outer side of the membrane, cytosol

• CHEBI:30249Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC25A2, SLC7A6, IDO1, TDO2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 3-acetamidopropanalReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. Transport by Y+Lat-2 into Extracellular Space
  3. N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming)

  Catalysed by SLC25A29, SLC3A2, SLC7A6, PAOX and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• formic acidReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by SLC25A29, SLC6A14, SLC26A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• malonic acidReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by SLC25A29, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC25A2, SLC7A6, IL4I1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by SLC25A2, SLC7A6, NDUFAB1, FDXR and 5 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC25A2, SLC7A6, BCAT2, BCAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• D-cysteineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• D-serineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 10 routes

• 5-aminolevulinateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC25A2, GATM, ALAS1, ALAS2inner side of the membrane, outer side of the membrane, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC25A2, SLC7A6, BCAT1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by SLC25A2, SLC7A6, GOT2, GOT1 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol

• glycochenodeoxycholic acidReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLC25A2, GATM, AADATinner side of the membrane, outer side of the membrane, cytosolOne of 12 routes

• glycolithocholic acidReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by SLC25A2, GATM, BAATinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC25A2, GATM, GCATinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrix

• gamma-Glu-AlaReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC25A2, SLC7A6, GGT1, GGT5 and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC25A2, GATM, GLDC, GCSHinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrix

• taurineReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC25A29, SLC6A14, SLC6A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• D-alanineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• sarcosineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by SLC25A2, GATM, PIPOXinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SLC25A2, GATM, SHMT1, SHMT2inner side of the membrane, outer side of the membrane, cytosol

• carnosineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
  3. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)

  Catalysed by SLC25A2, CARNS1inner side of the membrane, outer side of the membrane

• L-dopaReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A8inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• an N-acylglycineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by SLC25A2, GATM, GLYATL3, GLYAT and 1 moreinner side of the membrane, outer side of the membrane, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by SLC25A2, SLC7A6, GOT2, GOT1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• D-threonineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• spermidineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase

  Catalysed by SLC25A2, ODC1, SRMinner side of the membrane, outer side of the membrane, cytosolOne of 4 routes

• L-dopaquinoneReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,L-dopa:oxygen oxidoreductase

  Catalysed by SLC25A2, SLC7A6, TYRinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glutathioneReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by SLC25A2, GATM, GSSinner side of the membrane, outer side of the membrane, cytosol

• L-threonineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 8 routes

• L-saccharopineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

  Catalysed by SLC25A2, SLC7A5, SLC7A6, AASSinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• L-kynurenineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by SLC25A2, SLC7A6, KYNUinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• beta-alanineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by SLC25A2, SLC7A6, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• leukotriene C4Reach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-Arginine:glycine amidinotransferase
  3. leukotriene C4 hydrolysis

  Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosol

• dimethylamineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)
  3. Nomega,Nomega'-dimethyl-L-arginine dimethylamidohydrolase

  Catalysed by SLC25A2, DDAH1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 3-hydroxy-L-kynurenineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by SLC25A2, SLC7A6, KYNUinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• gamma-L-glutamyl-L-cysteineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by SLC25A2, SLC7A6, GCLC, GCLMinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 6-amino-2-oxohexanoateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. L-lysine:oxygen 2-oxidoreductase (deaminating)

  Catalysed by SLC25A2, SLC7A5, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol, peroxisomeOne of 2 routes

• L-homocysteineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC25A2, SLC7A6, BHMT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• carbamoyl phosphateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  3. Carbamoyl-phosphate:L-ornithine carbamoyltransferase

  Catalysed by SLC25A2, SLC7A9, OTCinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• S-methyl-L-methionineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC25A2, SLC7A6, BHMT2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-acetylputrescineReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. acetyl-CoA:putrescine N-acetyltransferase

  Catalysed by SLC25A2, ODC1, SAT1, SAT2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 4-aminobutanalReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. putrescine + O2 + H2O = 4-aminobutanal + H2O2 + NH4(+)

  Catalysed by SLC25A2, ODC1, AOC1inner side of the membrane, outer side of the membrane, cytosol

• L-glutamyl 5-phosphateReach from here →
  1. L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)
  2. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
  3. L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)

  Catalysed by SLC25A2, OAT, ALDH18A1inner side of the membrane, outer side of the membrane

• glutathione disulfideReach from here →
  1. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)
  2. L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)
  3. cystine to cysteine conversion

  Catalysed by SLC25A29, SLC7A9inner side of the membrane, outer side of the membrane, cytosol