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Proteins/UNIPROT:P54886
Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine..
Function from UniProtKB (P54886), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
8 rows
139 statements
139 statements · 6 reference databases · Subject: ALDH18A1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
(R)-lactaldehyde+water+NAD(+)(R)-lactic acid+2proton+NADH(2-)
Catalysed by ALDH18A1 or ALDH2 or ALDH5A1 or ALDH6A1 or ALDH1B1 or ALDH4A1
Reaction pageLeft to rightBalancedEC 1.2.1.3mitochondrial matrix
Human-GEM MAR01474CC BY 4.0Reference data
10 names
Resolves to: ALDH18A1
Catalysed by ALDH18A1
Reaction pageLeft to rightBalancedEC 2.7.2.11mitochondrial matrix
Human-GEM MAR03895CC BY 4.0Reference data
L-glutamyl 5-phosphate+proton+NADPH(4-)L-glutamic 5-semialdehyde+NADP(3-)+phosphate(3-)
Catalysed by ALDH18A1
Reaction pageLeft to rightBalancedEC 1.2.1.41mitochondrial matrix
Human-GEM MAR03897CC BY 4.0Reference data
proton+MAM02537m+NADPH(4-)MAM02535m+NADP(3-)+phosphate(3-)
Catalysed by ALDH18A1
Reaction pageLeft to rightBalancedEC 1.2.1.41mitochondrial matrix
Human-GEM MAR09557CC BY 4.0Reference data
L-glutamate(1-)+ATP(4-)L-glutamyl 5-phosphate+ADP(3-)
Catalysed by ALDH18A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:14877CC BY 4.0Reference data
L-glutamate 5-semialdehyde+hydrogenphosphate+NADP(3-)L-glutamyl 5-phosphate+NADPH(4-)+hydron
Catalysed by ALDH18A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:19541CC BY 4.0Reference data