cholesterol sulfate

Three steps

• isocitric acidReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by STS, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 6 routes

• glutarateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by STS, SLC22A24, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• pentanoateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by STS, SLC22A9cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• cis-aconitic acidReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by STS, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 6 routes

• N-carbamoyl-L-aspartateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by STS, SLC25A14, SLC25A30, CADcytosol, inner side of the membrane, outer side of the membrane

• a phenolReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by STS, ARSL, ARSF, ARSK and 3 morecytosol

• fatty acidReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase

  Catalysed by STS, LCAT, LYPLA1, LYPLA2 and 8 morecytosol

• glyoxylateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by STS, SLC25A10, CLYBLcytosol, mitochondrial matrix

• 7alpha,25-dihydroxycholesterolReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. cholesterol 25-hydroxylase (cholesterol)
  3. cytochrome P450 (25-hydroxycholesterol)

  Catalysed by STS, CH25H, CYP7B1cytosol, endoplasmic reticulumOne of 2 routes

• (24S)-7alpha-dihydroxycholesterolReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
  3. Oxysterol 7-Alpha-Hydroxylase

  Catalysed by STS, CYP46A1, CYP39A1cytosol, endoplasmic reticulumOne of 4 routes

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by STS, SLC4A1, ALDH9A1cytosol, extracellular space

• taurineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by STS, SOAT2, SOAT1, BAATcytosol, endoplasmic reticulumOne of 4 routes

• glycineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by STS, SOAT2, SOAT1, GLYAT and 2 morecytosol, endoplasmic reticulum, mitochondrial matrixOne of 13 routes

• (S)-malyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by STS, SLC25A10, SUCLG1, SUCLA2cytosol, mitochondrial matrix

• (R)-methylmalonyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by STS, SOAT2, SOAT1, ALDH6A1cytosol, endoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by STS, SOAT2, SOAT1cytosol, endoplasmic reticulum, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by STS, SOAT2, SOAT1, ACP2cytosol, endoplasmic reticulum, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by STS, SOAT2, SOAT1cytosol, endoplasmic reticulum, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by STS, SOAT2, SOAT1, ACAA1 and 1 morecytosol, endoplasmic reticulum, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 7 routes

• butanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by STS, SOAT2, SOAT1, ACSM4 and 5 morecytosol, endoplasmic reticulumOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 9 routes

• glutaryl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by STS, SOAT2, SOAT1, CPT1A and 2 morecytosol, endoplasmic reticulumOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 12 routes

• itaconyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by STS, SOAT2, SOAT1, SUCLG1 and 2 morecytosol, endoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 7 morecytosol, endoplasmic reticulumOne of 11 routes

• octanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by STS, SOAT2, SOAT1, CROTcytosol, endoplasmic reticulum, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. phytanate-CoA ligase

  Catalysed by STS, SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by STS, SOAT2, SOAT1, SLC27A2 and 6 morecytosol, endoplasmic reticulumOne of 15 routes

• prostaglandin F2alphaReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Folate Transport by Oats
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by STS, SLC22A8, SLC22A7, DHFR and 1 morecytosol, extracellular spaceOne of 3 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by STS, SLC25A10, ASLcytosol, mitochondrial matrixOne of 4 routes

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by STS, SLC25A10, ADSL, TNRC6Bcytosol, mitochondrial matrixOne of 4 routes

• guanidinoacetateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by STS, SLC26A6cytosol, extracellular space

• 3',5'-cyclic GMPReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sphing-4-enineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by STS, SOAT2, SOAT1, ASAH1 and 3 morecytosol, endoplasmic reticulum, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by STS, SOAT2, SOAT1, SAT1 and 1 morecytosol, endoplasmic reticulumOne of 3 routes

• L-methionineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by STS, SOAT2, SOAT1, NAGScytosol, endoplasmic reticulum, mitochondrial matrixOne of 5 routes

• adenosine 5'-phosphoramidateReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. ATP:sulfate adenylyltransferase
  3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

  Catalysed by STS, PAPSS1, PAPSS2, FHITcytosol

• L-tryptophanReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 4 routes

• glutathioneReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by STS, SLC25A14, SLC25A30, TSTD1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• beta-alanineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A6, SLC6A14cytosol, extracellular spaceOne of 4 routes

• L-alanineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by STS, SOAT2, SOAT1cytosol, endoplasmic reticulum, mitochondrial matrixOne of 4 routes

• L-asparagineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by STS, SOAT2, SOAT1, NAGScytosol, endoplasmic reticulum, mitochondrial matrixOne of 5 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by STS, SLC25A14, SLC25A30, AGAcytosol, inner side of the membrane, outer side of the membrane

• L-phenylalanineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 4 routes

• L,L-cystathionineReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. Sterol O-Acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by STS, SOAT2, SOAT1, NAGScytosol, endoplasmic reticulum, mitochondrial matrix

• 3',5'-cyclic AMPReach from here →
  1. Cholesterol-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes