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ReactionsRhea and Human-GEM, by subsystem
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PathwaysReactions grouped under one name
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Reference

Evidence

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Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

Reach

7alpha,25-dihydroxycholesterol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

1 compound within 3 steps: 1 in 1, 0 in 2, 0 in 3

Does it reach a compound?

One step

7alpha,25-dihydroxy-4-cholesten-3-oneReach from here →
1. cholest-5-ene-3beta,7alpha,25-triol:NAD+ 3-oxidoreductase
Catalysed by HSD3B7endoplasmic reticulumOne of 2 routes