Compound

(24S)-7alpha-dihydroxycholesterol

A 7α,24-dihydroxycholesterol in which has S configuration at position 24.

Definition from ChEBI (CHEBI:37640), read 2026-09-23. CC BY 4.0.

CHEBI:37640ChEBI

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Structure

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A generated conformer of (24S)-7alpha-dihydroxycholesterol — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound
Formula: C27H46O3
Mass: 418.662 g/mol
Charge: 0
InChIKey: ZNCHPOYZMVVJCK-LIZWOPGQSA-N
SMILES: [H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@]3([H])[C@H](C)CC[C@H](O)C(C)C)[C@]1([H])[C@H](O)C=C1C[C@@H](O)CC[C@@]12C
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

1 entity

1 entities reached.

0 reported hops1 assembled from the scaffold

HSD3B7ProteinUNIPROT:Q9H2F3substrate ofInferred only20 paths10 endpoints

What the reference databases state

Statements

4 statements

4 statements · 2 reference databases · Subject: (24S)-7alpha-dihydroxycholesterol · Sources: Human-GEM, Rhea

Order

(24S)-hydroxycholesterol is converted to (24S)-7alpha-dihydroxycholesterolCompoundHuman-GEM MAR01569Inferred only
(24S)-hydroxycholesterol is converted to (24S)-7alpha-dihydroxycholesterolCompoundHuman-GEM MAR01737Inferred only
(24S)-7alpha-dihydroxycholesterol is a substrate of HSD3B7ProteinHuman-GEM MAR01738Inferred only
(24S)-7alpha-dihydroxycholesterol is a substrate of HSD3B7ProteinRhea RHEA:47200Inferred only

Reactions

9 reactions

(24S)-7alpha-dihydroxycholesterol
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR00720CC BY 4.0Reference data
(24S)-hydroxycholesterol+proton+NADPH(4-)+dioxygen(24S)-7alpha-dihydroxycholesterol+water+NADP(3-)
Catalysed by CYP39A1
Reaction pageLeft to rightBalancedEC 1.14.15.15endoplasmic reticulum
Human-GEM MAR01569CC BY 4.0Reference data
(24S)-hydroxycholesterol+proton+NADPH(4-)+dioxygen(24S)-7alpha-dihydroxycholesterol+water+NADP(3-)
Catalysed by CYP39A1
Reaction pageLeft to rightBalancedEC 1.14.14.26cytosol
Human-GEM MAR01737CC BY 4.0Reference data
(24S)-7alpha-dihydroxycholesterol+NAD(+)MAM00978c+proton+NADH(2-)
Catalysed by HSD3B7
Reaction pageLeft to rightBalancedEC 1.1.1.181cytosol
Human-GEM MAR01738CC BY 4.0Reference data
(24S)-7alpha-dihydroxycholesterol(24S)-7alpha-dihydroxycholesterol
Reaction pageReversibleBalancedEC 6.2.1.7endoplasmic reticulum, cytosol
Human-GEM MAR01829CC BY 4.0Reference data
(24S)-7alpha-dihydroxycholesterol(24S)-7alpha-dihydroxycholesterol
Reaction pageReversibleBalancedEC 6.2.1.7cytosol, extracellular space
Human-GEM MAR01849CC BY 4.0Reference data
(24S)-hydroxycholesterol+reduced [NADPH--hemoprotein reductase]+dioxygen(24S)-7alpha-dihydroxycholesterol+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP7B1 or CYP7A1 or CYP39A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46124CC BY 4.0Reference data
7alpha-hydroxycholesterol+reduced [NADPH--hemoprotein reductase]+dioxygen(24S)-7alpha-dihydroxycholesterol+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP46A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46380CC BY 4.0Reference data
(24S)-7alpha-dihydroxycholesterol+NAD(1-)CHEBI:63838+NADH(2-)+hydron
Catalysed by HSD3B7
Reaction pageLeft to rightBalanced
Rhea RHEA:47200CC BY 4.0Reference data

Other names

6 names

Resolves to: (24S)-7alpha-dihydroxycholesterol

Also called: (24S)-Cholest-5-ene-3beta,7alpha,24-triol5-Cholesten-3beta,7alpha,24(S)-triol7alpha,24S-dihydroxycholesterolcholest-5-en-3beta,7alpha,24S-triolST 27:1;O3
Systematic name: (24S)-cholest-5-ene-3β,7α,24-triol